ATR-FTIR spectroscopy and spectroscopic imaging for the analysis of biopharmaceuticals

被引:144
作者
Tiernan, Hannah [1 ,2 ]
Byrne, Bernadette [2 ]
Kazarian, Sergei G. [1 ]
机构
[1] Imperial Coll London, Dept Chem Engn, London, England
[2] Imperial Coll London, Dept Life Sci, London, England
基金
英国生物技术与生命科学研究理事会;
关键词
FTIR spectroscopy; ATR; Proteins; Biopharmaceuticals; Bioprocessing; Aggregation; PROTEIN SECONDARY STRUCTURE; CLEANING-IN-PLACE; MONOCLONAL-ANTIBODY; INFRARED-SPECTROSCOPY; CIRCULAR-DICHROISM; IR SPECTROSCOPY; SPECTRA; TIME; GLYCOSYLATION; BIOSIMILARS;
D O I
10.1016/j.saa.2020.118636
中图分类号
O433 [光谱学];
学科分类号
0703 ; 070302 ;
摘要
Attenuated Total Reflection Fourier Transform Infrared (ATR-FTIR) spectroscopy is a label-free, non-destructive technique that can be applied to a vast range of biological applications, from imaging cancer tissues and live cells, to determining protein content and protein secondary structure composition. This review summarises the recent advances in applications of ATR-FTIR spectroscopy to biopharmaceuticals, the application of this technique to biosimilars, and the current uses of FTIR spectroscopy in biopharmaceutical production. We discuss the use of ATR-FTIR spectroscopic imaging to investigate biopharmaceuticals, and finally, give an outlook on the possible future developments and applications of ATR-FTIR spectroscopy and spectroscopic imaging to this field. Throughout the review comparisons will be made between FTIR spectroscopy and alternative analytical techniques, and areas will be identified where FTIR spectroscopy could perhaps offer a better alternative in future studies. This review focuses on the most recent advances in the field of using ATR-FTIR spectroscopy and spectroscopic imaging to characterise and evaluate biopharmaceuticals, both in industrial and academic research based environments. (C) 2020 Elsevier B.V. All rights reserved.
引用
收藏
页数:11
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