Going local: technologies for exploring bacterial microenvironments

被引：99

作者：

Wessel, Aimee K. ^{[1
]}

Hmelo, Laura ^{[2
]}

Parsek, Matthew R. ^{[2
]}

Whiteley, Marvin ^{[1
]}

机构：

[1] Univ Texas Austin, Inst Cell & Mol Biol, Sect Mol Genet & Microbiol, Austin, TX 78772 USA

[2] Univ Washington, Dept Microbiol, Seattle, WA 98195 USA

来源：

NATURE REVIEWS MICROBIOLOGY | 2013年 / 11卷 / 05期

关键词：

SCANNING ELECTROCHEMICAL MICROSCOPY; IMAGING MASS-SPECTROMETRY; CHEMOTACTIC RESPONSE; MICROFLUIDIC DEVICE; NITROGEN-FIXATION; SPATIAL STRUCTURE; NUTRIENT PATCHES; MARINE-BACTERIA; CELL; BIOFILM;

D O I：

10.1038/nrmicro3010

中图分类号：

Q93 [微生物学];

学科分类号：

071005 ; 100705 ;

摘要：

Microorganisms lead social lives and use coordinated chemical and physical interactions to establish complex communities. Mechanistic insights into these interactions have revealed that there are remarkably intricate systems for coordinating microbial behaviour, but little is known about how these interactions proceed in the spatially organized communities that are found in nature. This Review describes the technologies available for spatially organizing small microbial communities and the analytical methods for characterizing the chemical environment surrounding these communities. Together, these complementary technologies have provided novel insights into the impact of spatial organization on both microbial behaviour and the development of phenotypic heterogeneity within microbial communities.

引用

页码：337 / 348

页数：12

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