Epilepsy and cysticercosis in North-West Cameroon: A serological study

被引：16

作者：

Elliott, Irene ^{[1
]}

Jerome, Ambanibe ^{[2
]}

Angwafor, Samuel A. ^{[3
,4
]}

Smith, Mary Lou ^{[1
,5
]}

Takougang, Innocent ^{[6
]}

Noh, John ^{[7
]}

Tsang, Victor ^{[7
]}

Wilkins, Patricia ^{[7
]}

Cockburn, Lynn ^{[5
]}

Keystone, Jay ^{[5
]}

Njamnshi, Alfred K. ^{[8
]}

Snead, O. Carter, III ^{[1
,5
]}

机构：

[1] Hosp Sick Children, Toronto, ON M5G 1X8, Canada

[2] Assoc Orphans & Disabled, Teze, Cameroon

[3] Cent Hosp Yaounde, Batibo, Cameroon

[4] Batibo Dist Hosp, Batibo, Cameroon

[5] Univ Toronto, Toronto, ON, Canada

[6] Dept Publ Hlth, Yaounde, Cameroon

[7] Ctr Dis Control & Prevent, Atlanta, GA USA

[8] Minist Publ Hlth, Yaounde, Cameroon

来源：

SEIZURE-EUROPEAN JOURNAL OF EPILEPSY | 2013年 / 22卷 / 04期

关键词：

Taenia solium; Seropositivity; Seizures; Epilepsy; Cysticercosis; Case-control; Africa; Cameroon; NEUROCYSTICERCOSIS; TOXOCARIASIS; SEIZURES;

D O I：

10.1016/j.seizure.2013.01.012

中图分类号：

R74 [神经病学与精神病学];

学科分类号：

摘要：

Purpose: The prevalence of epilepsy in Cameroon is higher than that of the industrialized world and other developing countries. Neurocysticercosis due to Taenia solium infestation has been reported as a major cause of epilepsy in some parts of Cameroon although there are some conflicting data. The prevalence of epilepsy is especially high in the Momo division of the North-West Province of Cameroon. We hypothesized that individuals with epilepsy in this region have a higher percentage of seropositivity to T. solium than matched controls. Methods: We conducted a case-control study in the Momo subdivision of Ngie. Individuals with epilepsy were recruited from the health centers in Ngie. Control subjects were selected from 19 Ngie villages. Potential cases of people with epilepsy (PWE) were identified through a questionnaire applied by trained field workers, using history of epileptic seizures as a key indicator. Blood samples were taken from all consenting individuals by finger prick, stored in StabilZyme Select, and assayed for antibodies to T. solium in an Atlanta based reference laboratory. Results: We accrued 249 patients with epilepsy, of whom 237 met the inclusion criteria, and 245 age-matched controls. There was no significant difference in seropositivity to T. solium between those individuals with epilepsy (5%) and controls (4.9%). Conclusions: Our data do not support the hypothesis that epilepsy is associated with seropositivity to T. solium. It is highly unlikely that cysticercosis plays a causative role in the high prevalence of epilepsy in this region of Cameroon. (C) 2013 British Epilepsy Association. Published by Elsevier Ltd. All rights reserved.

引用

页码：283 / 286

页数：4

共 22 条

[1] Relationship between onchocerciasis and epilepsy: a matched case-control study in the Mbam Valley, Republic of Cameroon [J].