Highly enantioselective carbonyl reduction with borane catalyzed by chiral spiroborate esters derived from chiral 1,2-aminoalcohols

被引：32
|
作者：
Stepanenko, V [1 ]
Ortiz-Marciales, M [1 ]
Correa, W [1 ]
De Jesús, M [1 ]
Espinosa, S [1 ]
Ortiz, L [1 ]
机构：
[1] Univ Puerto Rico, Dept Chem, CUH Stn, Humacao, PR 00791 USA
来源：
TETRAHEDRON-ASYMMETRY | 2006年 / 17卷 / 01期
基金：
美国国家卫生研究院;
关键词：
D O I：
10.1016/j.tetasy.2005.12.005
中图分类号：
O61 [无机化学];
学科分类号：
070301 ; 081704 ;
摘要：
Novel spiroborate esters derived from nonracemic 1,2-amino alcohols were examined as chiral catalysts in the borane reduction of acetophenone and other aromatic ketones at room temperature. The optically active alcohols were obtained in excellent chemical yields and enantioselectivities up to 99% ee with 10% of catalyst. (c) 2006 Published by Elsevier Ltd.
引用
收藏
页码：112 / 115
页数：4
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