Cross-protection induced by Toxoplasma gondii virus-like particle vaccine upon intraperitoneal route challenge

被引：15
作者：
Lee, Dong-Hun [1 ]
Kim, Ah-Ra [1 ]
Lee, Su-Hwa [1 ]
Quan, Fu-Shi [2 ]
机构：
[1] Kyung Hee Univ, Grad Sch, Dept Biomed Sci, Seoul, South Korea
[2] Kyung Hee Univ, Dept Med Zool, Sch Med, Seoul, South Korea
来源：
ACTA TROPICA | 2016年 / 164卷
基金：
新加坡国家研究基金会;
关键词：
Toxoplasma gondii; Virus-like particle; Inner membrane complex; Vaccine; Protection; INNER MEMBRANE COMPLEX; IMMUNE PROTECTION; BALB/C MICE; PROTEIN; INFECTION; RESPONSES; LINEAGES; RATS; RSV;
D O I：
10.1016/j.actatropica.2016.08.025
中图分类号：
R38 [医学寄生虫学]; Q [生物科学];
学科分类号：
07 ; 0710 ; 09 ; 100103 ;
摘要：
The inner membrane complex sub-compartment has a critical role in Toxoplasma gondii endodyogeny. In this study, we investigated the protection upon intraperitoneal route (IP) challenge induced by the virus-like particles (VLPs) vaccine containing Toxoplasma gondii IMC ISP (RH strain) (Type I). Intranasal immunization with the VLPs in mice elicited enhanced systemic and mucosal Toxoplasma gondii-specific IgG, IgG1, IgG2a and IgA antibody responses, and CD4+ and CD8+ responses. Immunized mice significantly reduced T. gondii cyst burden and size in brain, resulting in cross-protection upon T. gondii (ME49) (Type II) challenge infection. These results indicate that the IP route challenge infection induced by T. gondii IMC ISP VLPs might be a very good target for vaccination representing novel approach to reduce infection. (C) 2016 Elsevier B.V. All rights reserved.
引用
收藏
页码：77 / 83
页数：7
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