Design, synthesis and antimicrobial activities of 1,2,3-triazole derivatives

被引：28

作者：

Zhao, Xu ^{[1
]}

Lu, Bo Wei ^{[2
]}

Lu, Jun Rui ^{[1
]}

Xin, Chun Wei ^{[1
]}

Li, Jian Fa ^{[1
]}

Liu, Ya ^{[1
]}

机构：

[1] Tianjin Univ Technol, Coll Chem & Chem Engn, Tianjin 300384, Peoples R China

[2] Nankai Univ, Coll Chem, Tianjin 300071, Peoples R China

来源：

CHINESE CHEMICAL LETTERS | 2012年 / 23卷 / 08期

基金：

中国国家自然科学基金;

关键词：

1-(4-Substituted phenyl)-4-(4-bromophenyl)-5-(halo-o-hydroxyphenyl)imino-1,2,3-triazoles; 1-(4-Substituted phenyl)-4-(4-bromophenyl)-5-amino-1,2,3-triazoles; Synthesis; Antimicrobial activity;

D O I：

10.1016/j.cclet.2012.06.014

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

Fifteen 1-(4-substituted phenyl)-4-(4-bromophenyl)-5-(halo-o-hydroxyphenyl)imino-1,2,3-triazoles were designed and synthesized based on rational combination of 1,2,3-triazoles and (halo)o-hydroxyphenyl group according to the superposition principle of reinforcement of biological activities. All the compounds were tested to an in vitro antimicrobial screening against M.a. and E.c.. Compounds IIe-IIo exhibited more potent antimicrobial activities against M.a. and E.c. than triclosan and fluconazole, which provided valuable information to further study of novel antimicrobial research. (C) 2012 Jun Rui Lu. Published by Elsevier B.V. on behalf of Chinese Chemical Society. All rights reserved.

引用

页码：933 / 935

页数：3

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