Interactions between vascular endothelial growth factor and neuroglobin

被引：25
|
作者：
Jin, Kunlin [1 ,2 ]
Mao, Xiao [1 ]
Xie, Lin [1 ]
Greenberg, David A. [1 ]
机构：
[1] Buck Inst Res Aging, Novato, CA 94945 USA
[2] Univ N Texas, Dept Pharmacol & Neurosci, Ft Worth, TX 76107 USA
来源：
NEUROSCIENCE LETTERS | 2012年 / 519卷 / 01期
关键词：
Vascular endothelial growth factor; Neuroglobin; Hypoxia; GENE-EXPRESSION; NEURAL CELLS; HYPOXIA; ANGIOGENESIS; NEURONS; KINASE; PROLIFERATION; TRANSCRIPTION; INDUCTION; ISCHEMIA;
D O I：
10.1016/j.neulet.2012.05.018
中图分类号：
Q189 [神经科学];
学科分类号：
071006 ;
摘要：
Vascular endothelial growth factor (VEGF) and neuroglobin (Ngb) participate in neuronal responses to hypoxia and ischemia, but the relationship between their effects, if any, is unknown. To address this issue, we measured Ngb levels in VEGF-treated mouse cerebrocortical cultures and VEGF levels in cerebrocortical cultures from Ngb-overexpressing transgenic mice. VEGF stimulated Ngb expression in a VEGFR2/Flk1 receptor-dependent manner, whereas Ngb overexpression suppressed expression of VEGF. These findings provide further insight into hypoxia-stimulated neuronal signaling pathways. (C) 2012 Elsevier Ireland Ltd. All rights reserved.
引用
收藏
页码：47 / 50
页数：4
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