A case report of nephrotic syndrome due to collapsing focal segmental glomerulosclerosis treated with low-density lipoprotein apheresis

被引:8
|
作者
Miyazono, Motoaki [1 ]
Tomiyoshi, Yoshiyuki [2 ]
Kishi, Tomoya [1 ]
Ikeda, Yuji [1 ]
Sakemi, Takanobu [1 ]
Sanai, Toru [1 ]
Node, Koichi [1 ]
机构
[1] Saga Univ, Dept Internal Med, Fac Med, Saga 8498501, Japan
[2] Saga Prefectural Hosp, Dept Renal Med, Saga, Japan
关键词
collapsing focal segmental glomerulosclerosis; low-density lipoprotein apheresis; nephrotic syndrome;
D O I
10.1111/j.1744-9987.2008.00596.x
中图分类号
R5 [内科学];
学科分类号
1002 ; 100201 ;
摘要
We herein report the case of a 73-year-old woman with steroid and cyclosporine resistant collapsing focal segmental glomerulosclerosis (FSGS) whose refractory proteinuria and hypoproteinemia were controlled with low-density lipoprotein apheresis (LDL-A). She was initially treated with steroid therapy, including methylprednisolone pulse and cyclosporine therapy. However, her hypoproteinemia, accompanied with renal insufficiency, persisted despite these therapies. We treated her using LDL-A and found improvement in her urine protein excretion, hyperlipidemia, hypoproteinemia, and renal function as a result of this treatment. This suggests that LDL-A may therefore be an effective therapy for nephrotic syndrome due to collapsing FSGS.
引用
收藏
页码:333 / 336
页数:4
相关论文
共 50 条
  • [31] CASE REPORT: Collapsing Focal Segmental Glomerulosclerosis with Recovery of Renal Function
    David F. Stein
    Abdurhman Ahmed
    Vijaya Sunkhara
    Walid Khalbuss
    Digestive Diseases and Sciences, 2001, 46 (3) : 530 - 535
  • [35] Umbilical Cord Blood Transplantation-associated Nephrotic Syndrome Successfully Treated by Low-density Lipoprotein Apheresis
    Sugawara, Yuka
    Honda, Kenjiro
    Katagiri, Daisuke
    Nakamura, Motonobu
    Kawakami, Takahisa
    Nasu, Ryo
    Hayashi, Akimasa
    Shintani, Yukako
    Tojo, Akihiro
    Noiri, Eisei
    Kurokawa, Mineo
    Fukayama, Masashi
    Nangaku, Masaomi
    INTERNAL MEDICINE, 2016, 55 (19) : 2831 - 2836
  • [37] IMPACT OF LOW-DENSITY LIPOPROTEIN APHERESIS FOR NEPHROTIC SYNDROME IN A PATIENT WITH IMMUNOGLOBULIN M NEPHROPATHY
    Tanaka, Atsushi
    Nakamura, Tsukasa
    Sato, Eiichi
    Node, Koichi
    NEPHROLOGY, 2016, 21 (12) : 1073 - 1074
  • [38] Evaluation of efficacy of low-density lipoprotein apheresis to improve diabetic nephrotic syndrome.
    Yunoki, O
    Yasumoto, Y
    Miyashita, H
    Homan, H
    Haruta, T
    Ueda, T
    Uchida, Y
    Yoshidome, E
    Ikeda, T
    Arima, T
    JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY, 1996, 7 (09): : A0607 - A0607
  • [39] Low-density Lipoprotein Receptor Activities, Lipids, Apolipoprotein, and Clinical Course of Patients with Steroid-resistant Nephrotic Syndrome Treated with Low density Lipoprotein Apheresis: A Case Series
    Shima, Hisato
    Higashiguchi, Yusuke
    Doi, Toshio
    Harada, Megumi
    Okamoto, Takuya
    Inoue, Tomoko
    Tashiro, Manabu
    Okada, Kazuyoshi
    Minakuchi, Jun
    INTERNAL MEDICINE, 2024, 63 (03) : 433 - 438
  • [40] LOW-DENSITY LIPOPROTEIN METABOLISM IN THE NEPHROTIC SYNDROME
    WARWICK, GL
    CASLAKE, MJ
    BOULTONJONES, JM
    DAGEN, M
    PACKARD, CJ
    SHEPHERD, J
    METABOLISM-CLINICAL AND EXPERIMENTAL, 1990, 39 (02): : 187 - 192