A case report of nephrotic syndrome due to collapsing focal segmental glomerulosclerosis treated with low-density lipoprotein apheresis

被引：8

作者：

Miyazono, Motoaki ^{[1
]}

Tomiyoshi, Yoshiyuki ^{[2
]}

Kishi, Tomoya ^{[1
]}

Ikeda, Yuji ^{[1
]}

Sakemi, Takanobu ^{[1
]}

Sanai, Toru ^{[1
]}

Node, Koichi ^{[1
]}

机构：

[1] Saga Univ, Dept Internal Med, Fac Med, Saga 8498501, Japan

[2] Saga Prefectural Hosp, Dept Renal Med, Saga, Japan

来源：

THERAPEUTIC APHERESIS AND DIALYSIS | 2008年 / 12卷 / 04期

关键词：

collapsing focal segmental glomerulosclerosis; low-density lipoprotein apheresis; nephrotic syndrome;

D O I：

10.1111/j.1744-9987.2008.00596.x

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

We herein report the case of a 73-year-old woman with steroid and cyclosporine resistant collapsing focal segmental glomerulosclerosis (FSGS) whose refractory proteinuria and hypoproteinemia were controlled with low-density lipoprotein apheresis (LDL-A). She was initially treated with steroid therapy, including methylprednisolone pulse and cyclosporine therapy. However, her hypoproteinemia, accompanied with renal insufficiency, persisted despite these therapies. We treated her using LDL-A and found improvement in her urine protein excretion, hyperlipidemia, hypoproteinemia, and renal function as a result of this treatment. This suggests that LDL-A may therefore be an effective therapy for nephrotic syndrome due to collapsing FSGS.

引用

页码：333 / 336

页数：4

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