A case report of nephrotic syndrome due to collapsing focal segmental glomerulosclerosis treated with low-density lipoprotein apheresis

被引:8
|
作者
Miyazono, Motoaki [1 ]
Tomiyoshi, Yoshiyuki [2 ]
Kishi, Tomoya [1 ]
Ikeda, Yuji [1 ]
Sakemi, Takanobu [1 ]
Sanai, Toru [1 ]
Node, Koichi [1 ]
机构
[1] Saga Univ, Dept Internal Med, Fac Med, Saga 8498501, Japan
[2] Saga Prefectural Hosp, Dept Renal Med, Saga, Japan
关键词
collapsing focal segmental glomerulosclerosis; low-density lipoprotein apheresis; nephrotic syndrome;
D O I
10.1111/j.1744-9987.2008.00596.x
中图分类号
R5 [内科学];
学科分类号
1002 ; 100201 ;
摘要
We herein report the case of a 73-year-old woman with steroid and cyclosporine resistant collapsing focal segmental glomerulosclerosis (FSGS) whose refractory proteinuria and hypoproteinemia were controlled with low-density lipoprotein apheresis (LDL-A). She was initially treated with steroid therapy, including methylprednisolone pulse and cyclosporine therapy. However, her hypoproteinemia, accompanied with renal insufficiency, persisted despite these therapies. We treated her using LDL-A and found improvement in her urine protein excretion, hyperlipidemia, hypoproteinemia, and renal function as a result of this treatment. This suggests that LDL-A may therefore be an effective therapy for nephrotic syndrome due to collapsing FSGS.
引用
收藏
页码:333 / 336
页数:4
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