Secondary metabolites of Sophora mollis subsp griffithii (Stocks) Ali

被引：5

作者：

Atta-ur-Rahman ^{[1
]}

Haroone, M. Sohail ^{[1
]}

Tareen, Rasool Baksh ^{[4
]}

Mesaik, M. Ahmed ^{[2
]}

Jan, Saleem ^{[1
,3
]}

Abbaskhan, Ahmed ^{[1
]}

Asif, Muhammad ^{[2
]}

Gulzar, Tahsin ^{[1
]}

Al-Majid, Abdullah M. ^{[5
]}

Yousuf, Sammer ^{[1
]}

Choudhary, M. Iqbal ^{[1
,5
]}

机构：

[1] Univ Karachi, HEJ Res Inst Chem, Int Ctr Chem & Biol Sci, Karachi 75270, Pakistan

[2] Univ Karachi, Int Ctr Chem & Biol Sci, Dr Panjwani Ctr Mol Med & Drug Res, Karachi 75270, Pakistan

[3] Univ Sci & Technol, Dept Chem, Bannu 28100, Pakistan

[4] Univ Balochistan, Dept Bot, Quetta 87300, Pakistan

[5] King Saud Univ, Coll Sci, Dept Chem, Riyadh 11451, Saudi Arabia

来源：

PHYTOCHEMISTRY LETTERS | 2012年 / 5卷 / 03期

关键词：

Sophora mollis; Leguminoseae; Sophoranone; CD Spectrum; Immunomodulatory activity; CHIROPTICAL PROPERTIES; PTEROCARPAN; ISOFLAVONOIDS; SECUNDIFLORA;

D O I：

10.1016/j.phytol.2012.06.006

中图分类号：

Q94 [植物学];

学科分类号：

071001 ;

摘要：

Two new compounds, (+)-3,5,7-trihydroxy-3-[3'-hydroxy-2',4'-dimethoxy-5-(3-methyl-2-butenyl)]phenyl-(3R)-4H-1-benzopyran-4-one (1) and (-)-3-hydroxy-8,9-methylenedioxy-(6aR,11aS)-pterocarpan (2), were isolated from the methanolic extract of Sophora mollis subsp. griffithii. Two known compounds, beta-sitosterol (3) and 19 beta H-lupeol-methyl-ether (4), were also obtained for the first time from this plant. The structures of 1-4 were identified through their spectroscopic data. CD Spectroscopy was also utilized for the structure elucidation of compounds 1 and 2. Compounds 1, 3 and 4 were studied for their effects on immune cells and only 1 was found to be substantially active. (C) 2012 Phytochemical Society of Europe. Published by Elsevier B. V. All rights reserved.

引用

页码：613 / 616

页数：4

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