Wealth of opportunity - The C1 domain as a target for drug development

被引:71
作者
Blumberg, P. M. [1 ]
Kedei, N. [1 ]
Lewin, N. E. [1 ]
Yang, D. [1 ]
Czifra, G. [1 ]
Pu, Y. [1 ]
Peach, M. L. [2 ]
Marquez, V. E. [3 ]
机构
[1] NCI, Lab Canc Biol & Genet, Ctr Canc Res, Bethesda, MD 20892 USA
[2] NCI, Basic Res Program, SAIC Frederick Inc, Frederick, MD 21702 USA
[3] NCI, Med Chem Lab, Ctr Canc Res, Frederick, MD 21702 USA
关键词
protein kinase C; phorbol ester; RasGRP; bryostatin; C1; domain;
D O I
10.2174/138945008785132376
中图分类号
R9 [药学];
学科分类号
1007 ;
摘要
The diacylglycerol-responsive C1 domains of protein kinase C and of the related classes of signaling proteins represent highly attractive targets for drug development. The signaling functions that are regulated by C1 domains are central to cellular control, thereby impacting many pathological conditions. Our understanding of the diacylglycerol signaling pathways provides great confidence in the utility of intervention in these pathways for treatment of cancer and other conditions. Multiple compounds directed at these signaling proteins, including compounds directed at the C1 domains, are currently in clinical trials, providing strong validation for these targets. Extensive understanding of the structure and function of C1 domains, coupled with detailed insights into the molecular details of ligand - C1 domain interactions, provides a solid basis for rational and semi-rational drug design. Finally, the complexity of the factors contributing to ligand - C1 domain interactions affords abundant opportunities for manipulation of selectivity; indeed, substantially selective compounds have already been identified.
引用
收藏
页码:641 / 652
页数:12
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