Fabrication and characterization of cefazolin-loaded nanofibrous mats for the recovery of post-surgical wound

被引：21
作者：
Rath, Goutam [1 ,2 ]
Hussain, Taqadus [1 ]
Chauhan, Gaurav [1 ]
Garg, Tarun [1 ]
Goyal, Amit Kumar [1 ]
机构：
[1] ISF Coll Pharm, Dept Pharmaceut, Moga, Punjab, India
[2] Punjab Tech Univ, Jalandhar, India
来源：
ARTIFICIAL CELLS NANOMEDICINE AND BIOTECHNOLOGY | 2016年 / 44卷 / 08期
关键词：
Cefazolin; controlled drug release; gelatin nanofibers; post-operative wound healing; DRUG-DELIVERY SYSTEMS; CURRENT NANOTECHNOLOGICAL STRATEGIES; ELECTROSPUN NANOFIBERS; SCAFFOLDS; CARRIER; MANAGEMENT; DRESSINGS; CELL;
D O I：
10.3109/21691401.2015.1102741
中图分类号：
Q81 [生物工程学（生物技术）]; Q93 [微生物学];
学科分类号：
071005 ; 0836 ; 090102 ; 100705 ;
摘要：
The aim of the present study was to evaluate the wound healing performance of cefazolin-loaded gelatin nanofiber mats in post-operative wound. The obtained nanofibers were smooth, non-beaded and having diameter ranging from 620-680 nm. Nanofiber mats that are prepared exhibit high drug entrapment, excellent oxygen permeability and sustained drug release behavior. Further, medicated nanofiber mats showed an accelerated wound healing as compared to plain cefazolin. Macroscopical and histological evaluations demonstrated that cefazolin-loaded gelatin nanofiber showed increased epithelialization rate and collagen deposition. The results indicated that therapeutic strategies offer new prospects in the management of post-operative wound repair.
引用
收藏
页码：1783 / 1792
页数：10
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