Mitochondria and Hypoxia: Metabolic Crosstalk in Cell-Fate Decisions

被引：52

作者：

Bargiela, David ^{[1
,2
]}

Burr, Stephen P. ^{[1
,2
]}

Chinnery, Patrick F. ^{[1
,2
]}

机构：

[1] Cambridge Biomed Campus, MRC Mitochondrial Biol Unit, Cambridge CB2 0XY, England

[2] Univ Cambridge, Cambridge Biomed Campus, Dept Clin Neurosci, Cambridge Biomed Campus, Cambridge CB2 0QQ, England

来源：

TRENDS IN ENDOCRINOLOGY AND METABOLISM | 2018年 / 29卷 / 04期

基金：

英国医学研究理事会;

关键词：

DOMAIN-CONTAINING PROTEINS; INDUCIBLE FACTOR-I; EMBRYONIC STEM-CELLS; ALPHA-KETOGLUTARATE; REDUCTIVE CARBOXYLATION; OXYGEN-CONSUMPTION; DNA DEMETHYLATION; ONCOMETABOLITE; 2-HYDROXYGLUTARATE; TRANSCRIPTIONAL REGULATION; HISTONE DEMETHYLATION;

D O I：

10.1016/j.tem.2018.02.002

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Alterations in mitochondrial metabolism influence cell differentiation and growth. This process is regulated by the activity of 2-oxoglutarate (2OG)-dependent dioxygenases (2OGDDs) - a diverse superfamily of oxygen-consuming enzymes - through modulation of the epigenetic landscape and transcriptional responses. Recent reports have described the role of mitochondrial metabolites in directing 2OGDD-driven cell-fate switches in stem cells (SCs), immune cells, and cancer cells. An understanding of the metabolic mechanisms underlying 2OGDD autoregulation is required for therapeutic targeting of this system. We propose a model dependent on oxygen and metabolite availability and discuss how this integrates 2OGDD metabolic signalling, the hypoxic transcriptional response, and fate-determining epigenetic changes.

引用

页码：249 / 259

页数：11

共 121 条

[1] Emerging Roles of JmjC Domain-Containing Proteins [J].

Accari, Sandra L. ;

Fisher, Paul R. .

INTERNATIONAL REVIEW OF CELL AND MOLECULAR BIOLOGY, VOL 319, 2015, 319 :165-220

[2] Identification of a dehydrogenase acting on D-2-hydroxyglutarate rate [J].

Achouri, Y ;

Noël, G ;

Vertommen, D ;

Rider, MH ;

Veiga-Da-Cunha, M ;

Van Schaftingen, E .

BIOCHEMICAL JOURNAL, 2004, 381 (01) :35-42

[3] The role of mitochondria in the regulation of hypoxia-inducible factor 1 expression during hypoxia [J].

Agani, FH ;

Pichiule, P ;

Chavez, JC ;

LaManna, JC .

JOURNAL OF BIOLOGICAL CHEMISTRY, 2000, 275 (46) :35863-35867

[4] Ascorbate regulates haematopoietic stem cell function and leukaemogenesis [J].

Agathocleous, Michalis ;

Meacham, Corbin E. ;

Burgess, Rebecca J. ;

Piskounova, Elena ;

Zhao, Zhiyu ;

Crane, Genevieve M. ;

Cowin, Brianna L. ;

Bruner, Emily ;

Murphy, Malea M. ;

Chen, Weina ;

Spangrude, Gerald J. ;

Hu, Zeping ;

DeBerardinis, Ralph J. ;

Morrison, Sean J. .

NATURE, 2017, 549 (7673) :476-+

[5] The mitochondrial respiratory chain is essential for haematopoietic stem cell function [J].

Anso, Elena ;

Weinberg, Samuel E. ;

Diebold, Lauren P. ;

Thompson, Benjamin J. ;

Malinge, Sebastien ;

Schumacker, Paul T. ;

Liu, Xin ;

Zhang, Yuannyu ;

Shao, Zhen ;

Steadman, Mya ;

Marsh, Kelly M. ;

Xu, Jian ;

Crispino, John D. ;

Chandel, Navdeep S. .

NATURE CELL BIOLOGY, 2017, 19 (06) :614-+

[6] Oxygen Sensors at the Crossroad of Metabolism [J].

Aragones, Julian ;

Fraisl, Peter ;

Baes, Myriam ;

Carmeliet, Peter .

CELL METABOLISM, 2009, 9 (01) :11-22

[7] AG311, a small molecule inhibitor of complex I and hypoxia-induced HIF-1 α stabilization [J].

Bastian, Anja ;

Matsuzaki, Satoshi ;

Humphries, Kenneth M. ;

Pharaoh, Gavin A. ;

Doshi, Arpit ;

Zaware, Nilesh ;

Gangjee, Aleem ;

Ihnat, Michael A. .

CANCER LETTERS, 2017, 388 :149-157

[8] Vitamin C induces Tet-dependent DNA demethylation and a blastocyst-like state in ES cells [J].

Blaschke, Kathryn ;

Ebata, Kevin T. ;

Karimi, Mohammad M. ;

Zepeda-Martinez, Jorge A. ;

Goyal, Preeti ;

Mahapatra, Sahasransu ;

Tam, Angela ;

Laird, Diana J. ;

Hirst, Martin ;

Rao, Anjana ;

Lorincz, Matthew C. ;

Ramalho-Santos, Miguel .

NATURE, 2013, 500 (7461) :222-+

[9] Paracrine Induction of HIF by Glutamate in Breast Cancer: EglN1 Senses Cysteine [J].

Briggs, Kimberly J. ;

Koivunen, Peppi ;

Cao, Shugeng ;

Backus, Keriann M. ;

Olenchock, Benjamin A. ;

Patel, Hetalben ;

Zhang, Qing ;

Signoretti, Sabina ;

Gerfen, Gary J. ;

Richardson, Andrea L. ;

Witkiewicz, Agnieszka K. ;

Cravatt, Benjamin F. ;

Clardy, Jon ;

Kaelin, William G., Jr. .

CELL, 2016, 166 (01) :126-139

[10] Induction of HIF-2α is dependent on mitochondrial O2 consumption in an O2-sensitive adrenomedullary chromaffin cell line [J].

Brown, Stephen T. ;

Nurse, Colin A. .

AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY, 2008, 294 (06) :C1305-C1312

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