Cutaneous sarcoidosis in a chronic hepatitis C patient receiving pegylated interferon and ribavirin therapy

被引：5

作者：

Joshita, Satoru ^{[1
,6
]}

Shirahata, Kumiko ^{[2
]}

Yazaki, Yoshikazu ^{[8
]}

Okaniwa, Shinji ^{[1
]}

Nakamura, Yoshiyuki ^{[1
]}

Kimura, Takefumi ^{[1
,6
]}

Noami, Sugiko ^{[3
]}

Horigome, Reiko ^{[3
]}

Yagi, Hikaru ^{[4
]}

Ito, Nobuo ^{[5
]}

Yamazaki, Asami ^{[6
]}

Akahane, Yuki ^{[6
]}

Umemura, Takeji ^{[6
]}

Yoshizawa, Kaname ^{[6
,9
]}

Tanaka, Eiji ^{[6
]}

Ota, Masao ^{[7
]}

机构：

[1] Iida Municipal Hosp, Dept Gastroenterol, Iida, Japan

[2] Iida Municipal Hosp, Dept Gen Med, Iida, Japan

[3] Iida Municipal Hosp, Dept Dermatol, Iida, Japan

[4] Iida Municipal Hosp, Dept Resp Med, Iida, Japan

[5] Iida Municipal Hosp, Dept Pathol, Iida, Japan

[6] Shinshu Univ, Sch Med, Dept Med, Div Gastroenterol & Hepatol, Matsumoto, Nagano 3908621, Japan

[7] Shinshu Univ, Sch Med, Dept Legal Med, Matsumoto, Nagano 3908621, Japan

[8] Matsumoto Hosp, Matsumoto Med Ctr, Natl Hosp Org, Dept Cardiol, Matsumoto, Nagano, Japan

[9] Shinshu Ueda Med Ctr, Natl Hosp Org, Dept Gastroenterol, Ueda, Nagano, Japan

来源：

HEPATOLOGY RESEARCH | 2013年 / 43卷 / 07期

关键词：

human leukocyte antigen; pegylated interferon; ribavirin; sarcoidosis; OF-THE-LITERATURE; VIRUS-INFECTION; JAPANESE PATIENTS; CELL-ACTIVATION; ALPHA; ASSOCIATION; SUSCEPTIBILITY; PROGRESS; GENES; BTNL2;

D O I：

10.1111/hepr.12021

中图分类号：

R57 [消化系及腹部疾病];

学科分类号：

摘要：

A 61-year-old Japanese woman suffered from a small, painful, subcutaneous nodule on the sole of her foot that was 10mm across in diameter during pegylated interferon (PEG IFN) and ribavirin (RBV) combination therapy for chronic hepatitis C. Skin biopsy revealed multiple non-caseating granulomas composed of epithelioid histiocytes with multinucleate giant cells, which was consistent with sarcoidosis. Ophthalmologic examination revealed uveitis. Thoracic computed tomography (CT) showed multiple bilateral hilar lymphadenopathies and a diffuse micronodular interstitial pattern of the lungs. Genetic analysis indicated a probable homozygous haplotype of A*02:01-C*15:02-B*51:01-DRB1*16:02-DQB1*05:02 in human leukocyte antigen regions. The patient was observed carefully without any additional medication because no significant systemic symptoms were noted. Combination therapy was continued for 2months afterwards. She was asymptomatic for over 3years of follow up, and repeated hematological and biological investigations and chest CT showed improvement. In conclusion, clinicians should bear sarcoidosis in mind as a complication during PEG IFN and RBV combination therapy. They should also be aware of the usually good prognosis of PEG IFN-induced cutaneous sarcoidosis in order not to prematurely discontinue a treatment necessary for liver disease; maintenance of PEG IFN treatment may be advised with careful follow up.

引用

页码：801 / 807

页数：7

共 34 条

[21]

Ning Q, 1998, J IMMUNOL, V160, P3487

[22] Two critical genes (HLA-DRB1 and ABCF1) in the HLA region are associated with the susceptibility to autoimmune pancreatitis [J].