The specific features of free-radical processes and the antioxidant defense in the adult brain

被引：11
作者：
Galkina, O. V. [1 ]
机构：
[1] St Petersburg State Univ, St Petersburg, Russia
来源：
NEUROCHEMICAL JOURNAL | 2013年 / 7卷 / 02期
关键词：
free radicals; free-radical oxidation; antioxidant system; antioxidant defense; low molecular antioxidants; CNS; brain; GLUTATHIONE-S-TRANSFERASE; CENTRAL-NERVOUS-SYSTEM; LONG-TERM POTENTIATION; OXIDATIVE STRESS; RAT-BRAIN; SUPEROXIDE-DISMUTASE; IN-VIVO; LIPID-PEROXIDATION; NADPH OXIDASES; NITRIC-OXIDE;
D O I：
10.1134/S1819712413020025
中图分类号：
Q189 [神经科学];
学科分类号：
071006 ;
摘要：
Here we review the specific features of free-radical processes in the CNS. We review the pathways of the generation of reactive oxygen species in nervous nerve tissue, the specific parameters of substrates of free-radical oxidation, and the contents and activities of various antioxidants. We briefly describe some physiological effects of reactive oxygen species in the nervous tissue.
引用
收藏
页码：89 / 97
页数：9
相关论文
共 101 条
  • [1] Superoxide modification and inactivation of a neuronal receptor-like complex
    Agbas, A
    Chen, X
    Hong, O
    Kumar, KN
    Michaelis, EK
    [J]. FREE RADICAL BIOLOGY AND MEDICINE, 2002, 32 (06) : 512 - 524
  • [2] MODULATION OF N-METHYL-D-ASPARTATE RECEPTORS BY HYDROXYL RADICALS IN RAT CORTICAL-NEURONS IN-VITRO
    AIZENMAN, E
    [J]. NEUROSCIENCE LETTERS, 1995, 189 (01) : 57 - 59
  • [3] ANSARI KA, 1989, GROWTH DEVELOP AGING, V53, P117
  • [4] Tocopherols and tocotrienols in membranes: A critical review
    Atkinson, Jeffrey
    Epand, Raquel F.
    Epand, Richard M.
    [J]. FREE RADICAL BIOLOGY AND MEDICINE, 2008, 44 (05) : 739 - 764
  • [5] The role of glutathione in brain tumor drug resistance
    Backos, Donald S.
    Franklin, Christopher C.
    Reigan, Philip
    [J]. BIOCHEMICAL PHARMACOLOGY, 2012, 83 (08) : 1005 - 1012
  • [6] The NOX family of ROS-generating NADPH oxidases: Physiology and pathophysiology
    Bedard, Karen
    Krause, Karl-Heinz
    [J]. PHYSIOLOGICAL REVIEWS, 2007, 87 (01) : 245 - 313
  • [7] Oxygen, reactive oxygen species and tissue damage
    Bergamini, CM
    Gambetti, S
    Dondi, A
    Cervellati, C
    [J]. CURRENT PHARMACEUTICAL DESIGN, 2004, 10 (14) : 1611 - 1626
  • [8] Free radicals, mitochondria, and hypoxia-ischemia in the developing brain
    Blomgren, K
    Hagberg, H
    [J]. FREE RADICAL BIOLOGY AND MEDICINE, 2006, 40 (03) : 388 - 397
  • [9] Boldyrev A. A., 2003, Uspekhi Fiziologicheskikh Nauk, V34, P21
  • [10] Boldyrev A.A., 1998, KARNOZIN
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