Chiral γ-Aryl-1H-1,2,4-triazole Derivatives as Highly Potential Antifungal Agents: Design, Synthesis, Structure, and in Vitro Fungicidal Activities

被引：30

作者：

Cao, Xiufang ^{[1
]}

Li, Fei ^{[1
]}

Hu, Ming ^{[1
]}

Lu, Wenchang ^{[1
]}

Yu, Guang-Ao ^{[1
]}

Liu, Sheng Hua ^{[1
]}

机构：

[1] Cent China Normal Univ, Coll Chem, Minist Educ, Key Lab Pesticide & Chem Biol, Wuhan 430079, Peoples R China

来源：

JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY | 2008年 / 56卷 / 23期

基金：

中国国家自然科学基金;

关键词：

Synthesis; chirality; 1,2,4-triazole; antifungal activities;

D O I：

10.1021/jf8026843

中图分类号：

S [农业科学];

学科分类号：

09 ;

摘要：

A novel series of chiral gamma-aryl-1H-1,2,4-triazole derivatives as highly potential antifungal agents have been designed and synthesized conveniently by using the chiral auxiliary as a controlling reagent. All of the compounds exhibit moderate to high ee values reaching up to 99%, and the preliminary bioassay results demonstrated that most of the target compounds take on a significantly wide spectrum activity against Fusarium oxysporium, Rhizoctonia solani, Botrytis cinereapers, Gibberella zeae, Dothiorella gregaria, and Colletotrichum gossypii species.

引用

页码：11367 / 11375

页数：9

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