Opinion - Inherited epigenetic variation - revisiting soft inheritance

被引：809
作者：
Richards, EJ [1 ]
机构：
[1] Washington Univ, Dept Biol, St Louis, MO 63130 USA
来源：
NATURE REVIEWS GENETICS | 2006年 / 7卷 / 05期
基金：
美国国家科学基金会;
关键词：
D O I：
10.1038/nrg1834
中图分类号：
Q3 [遗传学];
学科分类号：
071007 ; 090102 ;
摘要：
Phenotypic variation is traditionally parsed into components that are directed by genetic and environmental variation. The line between these two components is blurred by inherited epigenetic variation, which is potentially sensitive to environmental inputs. Chromatin and DNA methylation-based mechanisms mediate a semi-independent epigenetic inheritance system at the interface between genetic control and the environment. Should the existence of inherited epigenetic variation alter our thinking about evolutionary change?
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页码：395 / U2
页数：8
相关论文
共 74 条
[31]   Developmental abnormalities and epimutations associated with DNA hypomethylation mutations [J].
Kakutani, T ;
Jeddeloh, JA ;
Flowers, SK ;
Munakata, K ;
Richards, EJ .
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1996, 93 (22) :12406-12411
[32]  
Kankel MW, 2003, GENETICS, V163, P1109
[33]   Resistance of IAPs to methylation reprogramming may provide a mechanism for epigenetic inheritance in the mouse [J].
Lane, N ;
Dean, W ;
Erhardt, S ;
Hajkova, P ;
Surani, A ;
Walter, J ;
Reik, W .
GENESIS, 2003, 35 (02) :88-93
[34]   Role of transposable elements in heterochromatin and epigenetic control [J].
Lippman, Z ;
Gendrel, AV ;
Black, M ;
Vaughn, MW ;
Dedhia, N ;
McCombie, WR ;
Lavine, K ;
Mittal, V ;
May, B ;
Kasschau, KD ;
Carrington, JC ;
Doerge, RW ;
Colot, V ;
Martienssen, R .
NATURE, 2004, 430 (6998) :471-476
[35]   siRNAs targeting an intronic transposon in the regulation of natural flowering behavior in Arabidopsis [J].
Liu, J ;
He, YH ;
Amasino, R ;
Chen, XM .
GENES & DEVELOPMENT, 2004, 18 (23) :2873-2878
[36]   DNA methylation density influences the stability of an epigenetic imprint and Dnmt3a/b -: Independent de novo methylation [J].
Lorincz, MC ;
Schübeler, D ;
Hutchinson, SR ;
Dickerson, DR ;
Groudine, M .
MOLECULAR AND CELLULAR BIOLOGY, 2002, 22 (21) :7572-7580
[37]   Absence of genome-wide changes in DNA methylation duping development of the zebrafish [J].
Macleod, D ;
Clark, VH ;
Bird, A .
NATURE GENETICS, 1999, 23 (02) :139-140
[38]   Active recruitment of DNA methyltransferases regulates interleukin 4 in thymocytes and T cells [J].
Makar, KW ;
Pérez-Melgosa, M ;
Shnyreva, M ;
Weaver, WM ;
Fitzpatrick, DR ;
Wilson, CB .
NATURE IMMUNOLOGY, 2003, 4 (12) :1183-1190
[39]   RNAi-mediated pathways in the nucleus [J].
Matzke, MA ;
Birchler, JA .
NATURE REVIEWS GENETICS, 2005, 6 (01) :24-35
[40]  
Mayr E., 1980, P1
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