Opinion - Inherited epigenetic variation - revisiting soft inheritance

被引：809
作者：
Richards, EJ [1 ]
机构：
[1] Washington Univ, Dept Biol, St Louis, MO 63130 USA
来源：
NATURE REVIEWS GENETICS | 2006年 / 7卷 / 05期
基金：
美国国家科学基金会;
关键词：
D O I：
10.1038/nrg1834
中图分类号：
Q3 [遗传学];
学科分类号：
071007 ; 090102 ;
摘要：
Phenotypic variation is traditionally parsed into components that are directed by genetic and environmental variation. The line between these two components is blurred by inherited epigenetic variation, which is potentially sensitive to environmental inputs. Chromatin and DNA methylation-based mechanisms mediate a semi-independent epigenetic inheritance system at the interface between genetic control and the environment. Should the existence of inherited epigenetic variation alter our thinking about evolutionary change?
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页码：395 / U2
页数：8
相关论文
共 74 条
[1]   Epigenetic transgenerational actions of endocrine disruptors and mate fertility [J].
Anway, MD ;
Cupp, AS ;
Uzumcu, M ;
Skinner, MK .
SCIENCE, 2005, 308 (5727) :1466-1469
[2]   CHEMICALLY INDUCED PARAMUTATION AT R LOCUS IN MAIZE [J].
AXTELL, JD ;
BRINK, RA .
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1967, 58 (01) :181-&
[3]   MOLECULAR MECHANISMS IN THE DEVELOPMENTAL REGULATION OF THE MAIZE SUPPRESSOR-MUTATOR TRANSPOSABLE ELEMENT [J].
BANKS, JA ;
MASSON, P ;
FEDOROFF, N .
GENES & DEVELOPMENT, 1988, 2 (11) :1364-1380
[4]   Vernalization requires epigenetic silencing of FLC by histone methylation [J].
Bastow, R ;
Mylne, JS ;
Lister, C ;
Lippman, Z ;
Martienssen, RA ;
Dean, C .
NATURE, 2004, 427 (6970) :164-167
[5]   EPIGENETIC CONTROL OF AN ENDOGENOUS GENE FAMILY IS REVEALED BY A NOVEL BLUE FLUORESCENT MUTANT OF ARABIDOPSIS [J].
BENDER, J ;
FINK, GR .
CELL, 1995, 83 (05) :725-734
[6]   RNA meets chromatin [J].
Bernstein, E ;
Allis, CD .
GENES & DEVELOPMENT, 2005, 19 (14) :1635-1655
[7]   Reading the DNA methylation signal [J].
Bird, A ;
Macleod, D .
COLD SPRING HARBOR SYMPOSIA ON QUANTITATIVE BIOLOGY, 2004, 69 :113-118
[8]   REPRESSION OF GENES BY DNA METHYLATION DEPENDS ON CPG DENSITY AND PROMOTER STRENGTH - EVIDENCE FOR INVOLVEMENT OF A METHYL-CPG BINDING-PROTEIN [J].
BOYES, J ;
BIRD, A .
EMBO JOURNAL, 1992, 11 (01) :327-333
[9]  
Burkhardt Richard W., 1995, The Spirit of System. Lamarck and Evolutionary Biology
[10]   X-inactivation profile reveals extensive variability in X-linked gene expression in females [J].
Carrel, L ;
Willard, HF .
NATURE, 2005, 434 (7031) :400-404
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