Main-chain imidazolium oligomer material as a selective biomimetic antimicrobial agent

被引：76

作者：

Liu, Lihong ^{[2
]}

Huang, Yuan ^{[1
]}

Riduan, Siti Nurhanna ^{[2
]}

Gao, Shujun ^{[2
]}

Yang, Yiyan ^{[2
]}

Fan, Weimin ^{[1
,3
]}

Zhang, Yugen ^{[2
]}

机构：

[1] Zhejiang Univ, Affiliated Hosp 1, Coll Med, State Key Lab Diag & Treatment Infect Dis, Hangzhou 310003, Zhejiang, Peoples R China

[2] Inst Bioengn & Nanotechnol, Singapore 138669, Singapore

[3] Med Univ S Carolina, Charleston, SC 29425 USA

来源：

BIOMATERIALS | 2012年 / 33卷 / 33期

基金：

中国国家自然科学基金;

关键词：

Main-chain imidazolium oligomer; Broad spectrum antimicrobial agent; Drug-resistant microbials; Haemoconipatible; High in vivo efficacy; HOST-DEFENSE PEPTIDES; DE-NOVO DESIGN; IONIC LIQUIDS; POLYMERS; ANTIBACTERIAL; SALTS; DERIVATIVES; MEMBRANES; BACTERIA; IMMUNITY;

D O I：

10.1016/j.biomaterials.2012.08.006

中图分类号：

R318 [生物医学工程];

学科分类号：

0831 ;

摘要：

Human health has been challenged by multi-drug-resistant microorganisms for several decades. Herein, we have developed a main-chain imidazolium oligomer (IBN-1) material to combat broad spectrum of pathogenic strains, including drug-resistant Klebsiella pneumoniae, Vancomycin-resistant enterococcus, Methicillin-resistant Staphylococcus aureus and fluconazole-resistant yeast Cryptococcus neoformans, while displaying minimal hemolysis (HC50/MIC values over 3000) and a very high therapeutic index of 37 for killing S. aureus under inflammatory conditions in vivo. (C) 2012 Elsevier Ltd. All rights reserved.

引用

页码：8625 / 8631

页数：7

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