Main-chain imidazolium oligomer material as a selective biomimetic antimicrobial agent

被引：76
作者：
Liu, Lihong [2 ]
Huang, Yuan [1 ]
Riduan, Siti Nurhanna [2 ]
Gao, Shujun [2 ]
Yang, Yiyan [2 ]
Fan, Weimin [1 ,3 ]
Zhang, Yugen [2 ]
机构：
[1] Zhejiang Univ, Affiliated Hosp 1, Coll Med, State Key Lab Diag & Treatment Infect Dis, Hangzhou 310003, Zhejiang, Peoples R China
[2] Inst Bioengn & Nanotechnol, Singapore 138669, Singapore
[3] Med Univ S Carolina, Charleston, SC 29425 USA
来源：
BIOMATERIALS | 2012年 / 33卷 / 33期
基金：
中国国家自然科学基金;
关键词：
Main-chain imidazolium oligomer; Broad spectrum antimicrobial agent; Drug-resistant microbials; Haemoconipatible; High in vivo efficacy; HOST-DEFENSE PEPTIDES; DE-NOVO DESIGN; IONIC LIQUIDS; POLYMERS; ANTIBACTERIAL; SALTS; DERIVATIVES; MEMBRANES; BACTERIA; IMMUNITY;
D O I：
10.1016/j.biomaterials.2012.08.006
中图分类号：
R318 [生物医学工程];
学科分类号：
0831 ;
摘要：
Human health has been challenged by multi-drug-resistant microorganisms for several decades. Herein, we have developed a main-chain imidazolium oligomer (IBN-1) material to combat broad spectrum of pathogenic strains, including drug-resistant Klebsiella pneumoniae, Vancomycin-resistant enterococcus, Methicillin-resistant Staphylococcus aureus and fluconazole-resistant yeast Cryptococcus neoformans, while displaying minimal hemolysis (HC50/MIC values over 3000) and a very high therapeutic index of 37 for killing S. aureus under inflammatory conditions in vivo. (C) 2012 Elsevier Ltd. All rights reserved.
引用
收藏
页码：8625 / 8631
页数：7
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