Respiratory Health Effects of Ambient Air Pollution: An Update

被引：34

作者：

Sava, Francesco ^{[1
,2
,3
]}

Carlsten, Chris ^{[1
,2
,3
]}

机构：

[1] Univ British Columbia, Air Pollut Exposure Lab APEL, Vancouver Coastal Hlth Res Inst, Vancouver Gen Hosp VGH Res Pavil, Vancouver, BC V5Z 1L8, Canada

[2] Vancouver Gen Hosp, Dept Med, Lung Ctr, Vancouver, BC V5Z 1M9, Canada

[3] Univ British Columbia, Air Pollut Exposure Lab APEL, Vancouver Coastal Hlth Res Inst, Vancouver, BC V5Z 1L8, Canada

来源：

CLINICS IN CHEST MEDICINE | 2012年 / 33卷 / 04期

关键词：

Air pollution; Gene; Environment; Respiratory health; Asthma; COPD; Lung cancer; LONG-TERM EXPOSURE; SOUTHERN CALIFORNIA COMMUNITIES; HARVARD; 6; CITIES; DIESEL EXHAUST; PARTICULATE MATTER; LUNG-FUNCTION; CARDIOVASCULAR-DISEASE; HOSPITAL ADMISSION; PROSPECTIVE COHORT; DIFFERING LEVELS;

D O I：

10.1016/j.ccm.2012.07.003

中图分类号：

R56 [呼吸系及胸部疾病];

学科分类号：

摘要：

There is new evidence for ambient air pollution (AAP) leading to an increased incidence of respiratory diseases in adults. Research has demonstrated that co-exposures have the potential to dramatically augment the effects of AAP and lower the threshold of effect of a given pollutant. Interactions between genes related to oxidative stress and AAP seem to significantly alter the effect of AAP on an individual and population basis. A better definition of vulnerable populations may bolster local or regional efforts to remediate AAP. Advances in genetic research tools have the potential to identify candidate genes that can guide further research.

引用

页码：759 / +

页数：12

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