Long-term outcome and prognostic factors of elderly patients with acute promyelocytic leukemia

被引：26

作者：

Ono, Takaaki ^{[1
]}

Takeshita, Akihiro ^{[1
]}

Kishimoto, Yuji ^{[2
]}

Kiyoi, Hitoshi ^{[3
]}

Okada, Masaya ^{[4
]}

Yamauchi, Takahiro ^{[5
]}

Tsuzuki, Motohiro ^{[6
]}

Horikawa, Kentaro ^{[7
]}

Matsuda, Mitsuhiro ^{[8
]}

Shinagawa, Katsuji ^{[9
]}

Monma, Fumihiko ^{[10
]}

Ohtake, Shigeki ^{[11
]}

Nakaseko, Chiaki ^{[12
]}

Takahashi, Masatomo ^{[13
]}

Kimura, Yukihiko ^{[14
]}

Iwanaga, Masako ^{[15
]}

Asou, Norio ^{[7
]}

Naoe, Tomoki ^{[3
]}

机构：

[1] Hamamatsu Univ Sch Med, Dept Internal Med, Hamamatsu, Shizuoka 4313192, Japan

[2] Kansai Med Univ, Dept Internal Med 1, Moriguchi, Osaka 570, Japan

[3] Nagoya Univ, Grad Sch Med, Dept Hematol Oncol, Nagoya, Aichi 4648601, Japan

[4] Hyogo Coll Med, Dept Internal Med, Div Hematol, Nishinomiya, Hyogo 6638501, Japan

[5] Univ Fukui, Dept Hematol & Oncol, Fukui 910, Japan

[6] Fujita Hlth Univ, Sch Med, Dept Med, Toyoake, Aichi 47011, Japan

[7] Kumamoto Univ, Sch Med, Dept Hematol, Kumamoto 860, Japan

[8] PL Gen Hosp, Dept Internal Med, Tondabayashi, Osaka, Japan

[9] Okayama Univ, Grad Sch, Dept Hematol & Oncol, Okayama 7008530, Japan

[10] Mie Univ, Grad Sch Med, Dept Hematol & Oncol, Tsu, Mie 514, Japan

[11] Kanazawa Univ, Grad Sch Med Sci, Dept Clin Lab Sci, Kanazawa, Ishikawa, Japan

[12] Chiba Univ Hosp, Dept Hematol, Chiba, Japan

[13] St Marianna Univ, Sch Med, Div Hematol & Oncol, Kawasaki, Kanagawa, Japan

[14] Tokyo Med Univ, Dept Internal Med 1, Tokyo, Japan

[15] Nagasaki Univ, Grad Sch Biomed Sci, Atom Bomb Dis Inst, Dept Mol Med, Nagasaki 852, Japan

来源：

CANCER SCIENCE | 2012年 / 103卷 / 11期

关键词：

TRANS-RETINOIC ACID; ARSENIC TRIOXIDE; CONSOLIDATION; GIMEMA; CHEMOTHERAPY; IDARUBICIN; ADULTS; REMISSION; EFFICACY; PROTOCOL;

D O I：

10.1111/j.1349-7006.2012.02390.x

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Studies focused on elderly acute promyelocytic leukemia (APL) are relatively limited. To evaluate prognostic impact in elderly APL, we compared the long-term outcome of elderly APL patients (60-70 years) with younger patients (15-59 years) treated with all-trans retinoic acid combined with anthracycline and cytarabine in the Japan Adult Leukemia Study Group (JALSG) APL97 study. Of 283 evaluable patients, 46 (16.3%) were elderly who had more frequent lower platelet (P = 0.04), lower albumin (P = 0.006) and performance status 3 (P = 0.02), higher induction death rate due to differentiation syndrome (P = 0.03), and non-relapse mortality (NRM) during consolidation therapy (P = 0.001). Overall survival was significantly inferior in elderly patients (P = 0.005), but disease-free survival and cumulative incidence of relapse were not. Better therapeutic approaches should be considered to reduce NRM during induction and consolidation therapy in elderly APL. This study was registered at http://www.umin.ac.jp/ctrj/ under C000000206. (Cancer Sci 2012; 103: 1974-1978)

引用

页码：1974 / 1978

页数：5

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