Association between body mass index and sperm quality and sperm DNA integrity. A large population study

被引：51

作者：

Oliveira, J. B. A. ^{[1
,2
]}

Petersen, C. G. ^{[1
,2
]}

Mauri, A. L. ^{[1
,2
]}

Vagnini, L. D. ^{[2
]}

Renzi, A. ^{[2
]}

Petersen, B. ^{[2
]}

Mattila, M. ^{[1
]}

Dieamant, F. ^{[1
,2
]}

Baruffi, R. L. R. ^{[1
,2
]}

Franco, J. G., Jr. ^{[1
,2
]}

机构：

[1] Ctr Human Reprod Prof Franco Jr, Ribeirao Preto, SP, Brazil

[2] Paulista Ctr Diag Res & Training, Ribeirao Preto, SP, Brazil

来源：

ANDROLOGIA | 2018年 / 50卷 / 03期

关键词：

body mass index; mitochondria; obesity; spermatozoon; LIVE BIRTH-RATES; SEMEN QUALITY; REPRODUCTIVE HORMONES; MALE-FERTILITY; UNITED-STATES; MALE PARTNERS; MALE OBESITY; OVERWEIGHT; PARAMETERS; IMPACT;

D O I：

10.1111/and.12889

中图分类号：

R69 [泌尿科学（泌尿生殖系疾病）];

学科分类号：

摘要：

This study aimed to analyse whether the functional quality of spermatozoa is associated with body mass index (BMI). Semen samples were obtained from 1824 men undergoing fertility evaluation/treatment. Semen analysis was performed using World Health Organization (WHO) criteria, and morphology was evaluated with the motile sperm organelle morphology examination (MSOME). The percentages of sperm DNA fragmentation (using TdT (terminal deoxynucleotidyl transferase)-mediated dUTP nick-end labelling (TUNEL) assays), sperm chromatin packaging/underprotamination (using chromomycin A3/CMA(3)), mitochondrial damage (using MitoTracker Green) and apoptosis (using annexin V) were also assessed. At least 200 spermatozoa were examined in each evaluation. The following BMI values were used as cut-off points: 24.9kg/m(2), 25-29.9kg/m(2) (overweight) and 30kg/m(2) (obese). High BMI negatively affects sperm concentration, vitality, motility and morphology (p<.05). Conversely, high BMI does not seem to be associated with impaired sperm DNA integrity, as assessed by DNA fragmentation, sperm protamination and sperm apoptosis (p>.05). However, increased BMI is associated with increased mitochondrial damage in spermatozoa (p<.05). In conclusion, given the adverse consequences of obesity and the possible effect of male BMI on assisted reproduction technology (ART) outcomes, the benefits of weight reduction should be discussed when counselling couples interested in fertility treatment.

引用

页数：10

共 74 条

[21] Effect of bariatric surgery on semen parameters and sex hormone concentrations: a prospective study [J].

El Bardisi, Haitham ;

Majzoub, Ahmad ;

Arafa, Mohamed ;

AlMalki, Ahmad ;

Al Said, Sami ;

Khalafalla, Kareim ;

Jabbour, Gaby ;

Basha, Moataz ;

Al Ansari, Abdulla ;

Sabanegh, Edmund, Jr. .

REPRODUCTIVE BIOMEDICINE ONLINE, 2016, 33 (05) :606-611

[22] Association between obesity and alteration of sperm DNA integrity and mitochondrial activity [J].

Fariello, Roberta M. ;

Pariz, Juliana R. ;

Spaine, Deborah M. ;

Cedenho, Agnaldo P. ;

Bertolla, Ricardo P. ;

Fraietta, Renato .

BJU INTERNATIONAL, 2012, 110 (06) :863-867

[23] Cause-specific excess deaths associated with underweight, overweight, and obesity [J].

Flegal, Katherine M. ;

Graubard, Barry I. ;

Williamson, David F. ;

Gail, Mitchell H. .

JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION, 2007, 298 (17) :2028-2037

[24] Association of All-Cause Mortality With Overweight and Obesity Using Standard Body Mass Index Categories A Systematic Review and Meta-analysis [J].

Flegal, Katherine M. ;

Kit, Brian K. ;

Orpana, Heather ;

Graubard, Barry I. .

JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION, 2013, 309 (01) :71-82

[25] Large nuclear vacuoles are indicative of abnormal chromatin packaging in human spermatozoa [J].

Franco, J. G., Jr. ;

Mauri, A. L. ;

Petersen, C. G. ;

Massaro, F. C. ;

Silva, L. F. I. ;

Felipe, V. ;

Cavagna, M. ;

Pontes, A. ;

Baruffi, R. L. R. ;

Oliveira, J. B. A. ;

Vagnini, L. D. .

INTERNATIONAL JOURNAL OF ANDROLOGY, 2012, 35 (01) :46-51

[26]

GHO Global Health Observatory data repository, 2016, OV OB

[27] Effects of Overweight and Obesity on the Spermogram Values and Levels of Reproductive Hormones in the Male Population of the European North of Russia [J].

Gutorova, N. V. ;

Kleshchyov, M. A. ;

Tipisova, E. V. ;

Osadchuk, L. V. .

BULLETIN OF EXPERIMENTAL BIOLOGY AND MEDICINE, 2014, 157 (01) :95-98

[28] Association of body mass index with some fertility markers among male partners of infertile couples [J].

Hajshafiha, Masoumeh ;

Ghareaghaji, Rasul ;

Salemi, Sedigheh ;

Sadegh-Asadi, Nahid ;

Sadeghi-Bazargani, Homayoun .

INTERNATIONAL JOURNAL OF GENERAL MEDICINE, 2013, 6 :447-451

[29] Exposures that may affect sperm DNA integrity: Two decades of follow-up in a pregnancy cohort [J].

Hakonsen, L. B. ;

Spano, M. ;

Bonde, J. P. ;

Olsen, J. ;

Thulstrup, A. M. ;

Ernst, E. ;

Ramau-Hansen, C. H. .

REPRODUCTIVE TOXICOLOGY, 2012, 33 (03) :316-321

[30] Does weight loss improve semen quality and reproductive hormones? results from a cohort of severely obese men [J].

Hakonsen, Linn Berger ;

Thulstrup, Ane Marie ;

Aggerholm, Anette Skaerbech ;

Olsen, Jorn ;

Bonde, Jens Peter ;

Andersen, Claus Yding ;

Bungum, Mona ;

Ernst, Emil Hagen ;

Hansen, Mette Lausten ;

Ernst, Erik Hagen ;

Ramlau-Hansen, Cecilia Host .

REPRODUCTIVE HEALTH, 2011, 8

← 1 2 3 4 5 6 7 8 →