Bowen's disease showing spontaneous complete regression associated with apoptosis

被引：14

作者：

Chisiki, M

Kawada, A

Akiyama, M

Itoh, Y

Tajima, S

Ishibashi, A

Yudate, F

机构：

[1] Natl Def Med Coll, Dept Dermatol, Tokorozawa, Saitama 3590042, Japan

[2] Teikyo Univ, Sch Med, Ichihara Hosp, Dept Dermatol, Chiba 2990111, Japan

来源：

BRITISH JOURNAL OF DERMATOLOGY | 1999年 / 140卷 / 05期

关键词：

apoptosis; Bowen's disease; Fas antigen; regression;

D O I：

10.1046/j.1365-2133.1999.02831.x

中图分类号：

R75 [皮肤病学与性病学];

学科分类号：

100206 ;

摘要：

Spontaneous regression is sometimes seen in malignant skin tumours. We report a 68-year-old woman whose Bowen's disease showed spontaneous complete regression. Prominent infiltration of T cells and increased vascularity were found in the upper dermis of the regressed lesion. Strong expression of Pas (APO-1/CD95) antigen, an apoptosis-related tumour necrosis factor receptor family protein, in the primary lesion and faint expression following regression suggest the involvement of Fas-mediated apoptosis in the spontaneous complete regression of our patient's Bowen's disease.

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收藏

页码：939 / 944

页数：6

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