Flavone Glycosides from the Aerial Parts of Stachys lavandulifolia Vahl

Background: Stachys lavandulifolia Vahl is an herbaceous perennial plant which its flowering aerial parts are used traditionally as gastrotonic, spasmolytic, sedative and for the treatment of gastrointestinal disorders. In the present study the aerial parts of this medicinal plant was investigated for its flavonoid glycosides content. Methods: n-butanol fraction derived from hydroalcoholic extract of S. lavandulifolia was subjected to phytochemical analysis using chromatography on Sephadex LH-20 and RP-18 silica gel columns. The structures of isolated compounds were identified using H-1-NMR, C-13-NMR and UV spectral analysis. Results: Four flavone glycosides, chrysocriol-7-O-beta-D-glucopyranoside (1), apigenin-7-O-(6 ''-O-acetyl)-beta-D-glucopyranoside (2), luteolin-7-O-beta-D-glucopyranoside (3), apigenin-7-O-beta-D-glucopyranoside (4), along with apigenin (5) and chlorogenic acid (6) were isolated from S. lavandulifolia aerial parts. Conclusion: Identification of these phenolic compounds with some known biological activities in S. lavandulifolia explains some medicinal properties reported for this species and make scientific rationale for its traditional uses.