Intracellular trafficking of somatostatin receptors

被引：44

作者：

Jacobs, Stefan ^{[1
]}

Schulz, Stefan ^{[1
]}

机构：

[1] Univ Wurzburg, Inst Pharmakol & Toxikol, D-97078 Wurzburg, Germany

来源：

MOLECULAR AND CELLULAR ENDOCRINOLOGY | 2008年 / 286卷 / 1-2期

关键词：

somatostatin receptors; receptor internalization; endosomal sorting; receptor recycling;

D O I：

10.1016/j.mce.2007.10.005

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

The somatostatin receptor subtypes 1-5 (sst(1)-sst(5)) exhibit different intracellular trafficking and endosomal sorting after agonist exposure. The internalization of the somatostatin receptor subtypes sst(2), sst(3) and sst(5) occurs to a much higher extent after somatostatin exposure than of sst(1) or sst(4). After endocytosis, sst(2) and sst(5) recycle to the plasma membrane, whereas sst(3) is predominantly down-regulated. This review will focus on the molecular mechanisms of the differential intracellular trafficking of sst(2), sst(3) and sst(5), and discusses our current knowledge on somatostatin receptor interacting proteins. (C) 2007 Elsevier Ireland Ltd. All rights reserved.

引用

页码：58 / 62

页数：5

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