Anti-HIV-1 activities of extracts from the medicinal plant Rhus chinensis

被引：35
作者：
Wang, RR
Gu, QO
Yang, LM
Chen, JJ
Li, SY
Zheng, YT [1 ]
机构：
[1] Chinese Acad Sci, Kunming Inst Zool, Lab Mol Immunopharmacol, Kunming 650223, Yunnan, Peoples R China
[2] Chinese Acad Sci, Kunming Inst Bot, State Key Lab Phytochem & Plant Resources W China, Kunming 650204, Yunnan, Peoples R China
[3] Chinese Acad Sci, Grad Sch, Beijing 100039, Peoples R China
[4] Kunming Med Coll, Fac Pharmaceut Sci, Kunming 650031, Yunnan, Peoples R China
来源：
JOURNAL OF ETHNOPHARMACOLOGY | 2006年 / 105卷 / 1-2期
基金：
中国国家自然科学基金;
关键词：
Rhus chinensis; HIV-1; anti-HIV activity; botanicals;
D O I：
10.1016/j.jep.2005.11.008
中图分类号：
Q94 [植物学];
学科分类号：
071001 ;
摘要：
Rhus chinensis, a species used in folk medicine by Chinese native people, the anti-HIV-1 activities of the petroleum ether, ethyl acetate, butanol and aqueous extract of Rhus chinensis, named as RC-1, RC-2, RC-3 and RC-4, respectively, was evaluated. The petroleum ether extract RC-1 can inhibit the syncytium formation and HIV-1 p24 antigen at non-cytotoxic concentrations, the 50% effective concentration (EC50) were 0.71 and 0.93 mu g/ml, respectively. The therapeutic index (TI) was about 100. RC-1 had no activity on inhibiting HIV-1 recombinant RT and RIV-1 entry into host cells. Results showed that RC-1 was effective against HIV-1 and Rhus chinensis would be a useful medicinal plant for the chemotherapy of HIV-1 infection. RC-1 might inhibit the post steps or target the new sites of HIV-1 replication. (c) 2005 Elsevier Ireland Ltd. All rights reserved.
引用
收藏
页码：269 / 273
页数：5
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