Castor Oil-Based Biodegradable Polyesters

被引：127
|
作者：
Kunduru, Konda Reddy [1 ]
Basu, Arijit [1 ]
Zada, Moran Haim [1 ]
Domb, Abraham J. [1 ]
机构：
[1] Hebrew Univ Jerusalem, Fac Med, Sch Pharm, Dept Med Chem & Nat Prod,Inst Drug Res, IL-91120 Jerusalem, Israel
来源：
BIOMACROMOLECULES | 2015年 / 16卷 / 09期
关键词：
POLYGLYCEROL POLYRICINOLEATE PGPR; LIPASE-CATALYZED SYNTHESIS; ACID-BASED COPOLYESTERS; IN-VITRO CHARACTERIZATION; RICINOLEIC ACID; DRUG-RELEASE; TERMINATED POLYANHYDRIDES; ENZYMATIC-SYNTHESIS; CHEMICAL-INDUSTRY; LACTIC-ACID;
D O I：
10.1021/acs.biomac.5b00923
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
This Review compiles the synthesis, physical properties, and biomedical applications for the polyesters based on castor oil and ricinoleic acid. Castor oil has been known for its medicinal value since ancient times. It contains similar to 90% ricinoleic acid, which enables direct chemical transformation into polyesters without interference of other fatty acids. The presence of ricinoleic acid (hydroxyl containing fatty acid) enables synthesis of various polyester/anhydrides. In addition, castor oil contains a cis-double bond that can be hydrogenated, oxidized, halogenated, and polymerized. Castor oil is obtained pure in large quantities from natural sources; it is safe and biocompatible.
引用
收藏
页码：2572 / 2587
页数：16
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