Stromal plasma cells expressing immunoglobulin G4 subclass in non-small cell Lung cancer

被引：57

作者：

Fujimoto, Masakazu ^{[1
]}

Yoshizawa, Akihiko ^{[1
,2
]}

Sumiyoshi, Shinji ^{[1
]}

Sonobe, Makoto ^{[3
]}

Kobayashi, Masashi ^{[3
]}

Koyanagi, Itsuko ^{[1
]}

Aini, Wulamujiang ^{[1
]}

Tsuruyama, Tatsuaki ^{[1
]}

Date, Hiroshi ^{[3
]}

Haga, Hironori ^{[1
]}

机构：

[1] Kyoto Univ Hosp, Dept Diagnost Pathol, Kyoto 6068507, Japan

[2] Shinshu Univ Hosp, Dept Lab Med, Matsumoto, Nagano 3908621, Japan

[3] Kyoto Univ Hosp, Dept Thorac Surg, Kyoto 6068507, Japan

来源：

HUMAN PATHOLOGY | 2013年 / 44卷 / 08期

关键词：

IgG4; Plasma cell; Lung carcinoma; Tissue microarray; OF-THE-LITERATURE; IGG4-RELATED DISEASE; AUTOIMMUNE PANCREATITIS; MEMBRANOUS NEPHROPATHY; IGG SUBCLASS; ADENOCARCINOMA; CLASSIFICATION; INFLAMMATION; MUTATIONS; IMPACT;

D O I：

10.1016/j.humpath.2013.01.002

中图分类号：

R36 [病理学];

学科分类号：

100104 ;

摘要：

Inflammatory cell infiltration in tumor stroma may represent the interaction between the tumor and the immune system. The significance of immunoglobulin (Ig) G4+ plasmacytic infiltration, however, is poorly understood. Here, we analyzed the number of stromal IgG4+ plasma cells and the IgG4/IgG ratio of plasma cells in 294 primary non-small cell lung cancers (NSCLCs) using tissue microarray (TMA) and conventional surgical specimens. In TMA, 35 (12%) cases of NSCLC revealed more than 20 IgG4+ plasma cells per high-power field. In surgical specimens, most (97%) of those IgG4+ plasma cell-enriched cases showed obliterative phlebitis or arteritis, one of the key morphologic features of IgG4-related disease, within or at the periphery of the tumor. Clinically, none of the patients showed symptoms associated with IgG4-related systemic diseases. In patients with stage I squamous cell carcinoma, IgG4-enriched stroma was significantly associated with a favorable prognosis (P = .04). In conclusion, considerable IgG4+ plasma cell infiltration can be seen in a minority of cases of NSCLC and might contribute to prognostic modulation of NSCLC. (C) 2013 Elsevier Inc. All rights reserved.

引用

页码：1569 / 1576

页数：8

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