Lactose as a "Trojan Horse" for Quantum Dot Cell Transport

被引：57

作者：

Benito-Alifonso, David ^{[1
]}

Tremel, Shirley ^{[1
]}

Hou, Bo ^{[1
]}

Lockyear, Harriet ^{[1
]}

Mantell, Judith ^{[3
]}

Fermin, David J. ^{[1
]}

Verkade, Paul ^{[3
]}

Berry, Monica ^{[2
]}

Galan, M. Carmen ^{[1
]}

机构：

[1] Univ Bristol, Sch Chem, Bristol BS8 1TS, Avon, England

[2] Univ Bristol, Sch Phys, NSQI, Bristol BS8 1F, Avon, England

[3] Univ Bristol, Wolfson Bioimaging Facil, Sch Biochem & Physiol & Pharmacol, Bristol BS8 1TD, Avon, England

来源：

ANGEWANDTE CHEMIE-INTERNATIONAL EDITION | 2014年 / 53卷 / 03期

基金：

英国工程与自然科学研究理事会; 英国生物技术与生命科学研究理事会;

关键词：

glycans; intracellular localization; multivalency; nanoparticles; quantum dots; GOLD NANOPARTICLES; PROTEIN; GLYCONANOPARTICLES; ENDOCYTOSIS; FATE;

D O I：

10.1002/anie.201307232

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

A series of glycan-coated quantum dots were prepared to probe the effect of glycan presentation in intracellular localization in HeLa and SV40 epithelial cells. We show that glycan density mostly impacts on cell toxicity, whereas glycan type affects the cell uptake and intracellular localization. Moreover, we show that lactose can act as a "Trojan horse" on bi-functionalized QDs to help intracellular delivery of other non-internalizable glycan moieties and largely avoid the endosomal/lysosomal degradative pathway.

引用

页码：810 / 814

页数：5

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