Excellent chiral introduction by diene iron-tricarbonyl moiety .3. Asymmetric synthesis of hydroxyethylidene dipeptide isostere using a diastereoselective 1,2-nucleophilic addition of organocerium reagents into a 1-azatriene Fe(CO)(3) complex

被引:0
作者
Takemoto, Y [1 ]
Takeuchi, J [1 ]
Matsui, E [1 ]
Iwata, C [1 ]
机构
[1] OSAKA UNIV, FAC PHARMACEUT SCI, SUITA, OSAKA 565, JAPAN
关键词
1,2-nucleophilic addition; 1-azatriene iron-tricarbonyl complex; organocerium reagent; 1,4-functionalization; iodocyclocarbamation; hydroxyethylidene dipeptide isostere;
D O I
暂无
中图分类号
R914 [药物化学];
学科分类号
100701 ;
摘要
A 1-iminobutadiene-iron tricarbonyl [Fe(CO)(3)] complex (1) reacts with various organometallic nucleophiles in a stereoselective manner, and especially, by use of organocerium reagents, only single secondary amine complexes (2) were obtained in good yields. Application of this methodology was demonstrated in the asymmetric synthesis of hydroxyethylidene dipeptide isostere from the chiral starting material N-{(2R)-(2E)-tricarbonyl[2-5-eta-2,4-pentadienylidene]iron} benzylamine (1b).
引用
收藏
页码:948 / 955
页数:8
相关论文
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