Association of Interleukin 7 Immunotherapy With Lymphocyte Counts Among Patients With Severe Coronavirus Disease 2019 (COVID-19)

被引:71
作者
Laterre, Pierre Francois [1 ]
Francois, Bruno [2 ,3 ,4 ]
Collienne, Christine [1 ]
Hantson, Philippe [1 ]
Jeannet, Robin [5 ]
Remy, Kenneth E. [6 ,7 ,8 ]
Hotchkiss, Richard S. [7 ,8 ,9 ]
机构
[1] Catholic Univ Louvain, St Luc Univ Hosp, Dept Crit Care Med, Ave Hippocrate 10, B-1200 Brussels, Belgium
[2] Univ Hosp Limoges, Intens Care Unit Dept, Limoges, France
[3] Univ Hosp Limoges, INSERM, Ctr Invest Clin 1435, Limoges, France
[4] Univ Hosp Limoges, Unite Mixte Rech 1092, Limoges, France
[5] Univ Hosp Limoges, Dept Intens Care Med & Anaesthesiol, Limoges, France
[6] Washington Univ, Sch Med, Dept Pediat, St Louis, MO 63110 USA
[7] Washington Univ, Sch Med, Dept Anesthesiol & Crit Care Med, St Louis, MO USA
[8] Washington Univ, Sch Med, Dept Med, St Louis, MO 63110 USA
[9] Washington Univ, Sch Med, Dept Surg, St Louis, MO 63110 USA
关键词
IL-7;
D O I
10.1001/jamanetworkopen.2020.16485
中图分类号
R5 [内科学];
学科分类号
1002 ; 100201 ;
摘要
[No abstract available]
引用
收藏
页数:5
相关论文
共 6 条
[1]   Flip the coin: IL-7 and IL-7R in health and disease [J].
Barata, Joao T. ;
Durum, Scott K. ;
Seddon, Benedict .
NATURE IMMUNOLOGY, 2019, 20 (12) :1584-1593
[2]   Interleukin-7 restores lymphocytes in septic shock: the IRIS-7 randomized clinical trial [J].
Francois, Bruno ;
Jeannet, Robin ;
Daix, Thomas ;
Walton, Andrew H. ;
Shotwell, Matthew S. ;
Unsinger, Jacqueline ;
Monneret, Guillaume ;
Rimmele, Thomas ;
Blood, Teresa ;
Morre, Michel ;
Gregoire, Anne ;
Mayo, Gail A. ;
Blood, Jane ;
Durum, Scott K. ;
Sherwood, Edward R. ;
Hotchkiss, Richard S. .
JCI INSIGHT, 2018, 3 (05)
[3]   Harnessing the biology of IL-7 for therapeutic application [J].
Mackall, Crystal L. ;
Fry, Terry J. ;
Gress, Ronald E. .
NATURE REVIEWS IMMUNOLOGY, 2011, 11 (05) :330-342
[4]   Postmortem examination of COVID-19 patients reveals diffuse alveolar damage with severe capillary congestion and variegated findings in lungs and other organs suggesting vascular dysfunction [J].
Menter, Thomas ;
Haslbauer, Jasmin D. ;
Nienhold, Ronny ;
Savic, Spasenija ;
Deigendesch, Helmut ;
Frank, Stephan ;
Turek, Daniel ;
Willi, Niels ;
Pargger, Hans ;
Bassetti, Stefano ;
Leuppi, Joerg D. ;
Cathomas, Gieri ;
Tolnay, Markus ;
Mertz, Kirsten D. ;
Tzankov, Alexandar .
HISTOPATHOLOGY, 2020, 77 (02) :198-209
[5]   The many faces of the anti-COVID immune response [J].
Vardhana, Santosha A. ;
Wolchok, Jedd D. .
JOURNAL OF EXPERIMENTAL MEDICINE, 2020, 217 (06)
[6]   Clinical Characteristics of 138 Hospitalized Patients With 2019 Novel Coronavirus-Infected Pneumonia in Wuhan, China [J].
Wang, Dawei ;
Hu, Bo ;
Hu, Chang ;
Zhu, Fangfang ;
Liu, Xing ;
Zhang, Jing ;
Wang, Binbin ;
Xiang, Hui ;
Cheng, Zhenshun ;
Xiong, Yong ;
Zhao, Yan ;
Li, Yirong ;
Wang, Xinghuan ;
Peng, Zhiyong .
JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION, 2020, 323 (11) :1061-1069