A new fluorescence turn-on chemosensor for nanomolar detection of Al3+ constructed from a pyridine-pyrazole system

被引：34
作者：
Naskar, Barnali [1 ]
Das, Kinsuk [2 ]
Mondal, Ramij R. [1 ]
Maiti, Dilip K. [1 ]
Requena, Alberto [3 ]
Pedro Ceron-Carrasco, Jose [4 ]
Prodhan, Chandraday [5 ]
Chaudhuri, Keya [5 ]
Goswami, Sanchita [1 ]
机构：
[1] Univ Calcutta, Dept Chem, 92 APC RD, Kolkata 700009, India
[2] Chandernagore Coll, Dept Chem, Hooghly 712136, W Bengal, India
[3] Univ Murcia, Dept Quim Fis, Fac Quim, E-30100 Murcia, Spain
[4] UCAM, Bioinformat & High Performance Comp Res Grp BIO H, Murcia 30107, Spain
[5] Indian Inst Chem Biol, CSIR, Mol & Human Genet Div, 4 Raja SC Mallick Rd, Kolkata 700032, India
来源：
NEW JOURNAL OF CHEMISTRY | 2018年 / 42卷 / 04期
关键词：
ANALYTES FLUOROGENIC DETECTION; SCHIFF-BASE; COPPER(II) COMPLEXES; SELECTIVE DETECTION; AQUEOUS-MEDIA; CRYSTAL-STRUCTURES; ALUMINUM TOXICITY; SENSOR; ZN2+; PYRIDOXAL;
D O I：
10.1039/c7nj03955g
中图分类号：
O6 [化学];
学科分类号：
0703 ;
摘要：
Herein, a new probe, 5-methyl-1-pyridin-2-yl-1H-pyrazole-3-carboxylic acid (1-pyridin-2-yl-ethylidene)-hydrazide (Hmppc), bearing a pyridine-pyrazole moiety, was synthesized, which offered potential for chemical sensing of Al3+. Investigations of the fluorescence behaviour of Hmppc in DMSO/H2O (2 : 8, v/v) solution under biologically relevant conditions in HEPES buffer (pH = 7.4) displayed a dramatic switch-on response to Al3+ as a result of chelation-induced enhanced fluorescence (CHEF). Detailed experimental studies reveal that Hmppc can detect Al3+ in solution with high sensitivity and selectivity, having a detection limit of 1.2 nM. Furthermore, to demonstrate the analytical potential of Hmppc, we validated our sensing system as a naked eye detector for Al3+. Interestingly, bioimaging studies on HepG2 cells demonstrated that Hmppc responded selectively towards Al3+, allowing real time detection of Al3+ in living cells.
引用
收藏
页码：2933 / 2941
页数：9
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