Modeling regulation of vascular tone following muscle contraction: Model development, validation and global sensitivity analysis

被引：4

作者：

Keijsers, J. M. T. ^{[1
,2
]}

Leguy, C. A. D. ^{[2
]}

Narracott, A. J. ^{[3
,4
]}

Rittweger, J. ^{[2
]}

van de Vosse, F. N. ^{[1
]}

Huberts, W. ^{[1
,5
]}

机构：

[1] Eindhoven Univ Technol, Dept Biomed Engn, POB 513, NL-5600 MB Eindhoven, Netherlands

[2] German Aerosp Ctr, Inst Aerosp Med, Cologne, Germany

[3] Univ Sheffield, Med Phys Grp, Dept Cardiovasc Sci, Sheffield, S Yorkshire, England

[4] Univ Sheffield, INSIGNEO Inst In Silico Med, Sheffield, S Yorkshire, England

[5] Maastricht Univ, Dept Biomed Engn, Maastricht, Netherlands

来源：

JOURNAL OF COMPUTATIONAL SCIENCE | 2018年 / 24卷

基金：

欧盟第七框架计划;

关键词：

Regulation of vascular tone; Metabolic regulation; Myogenic regulation; Baroreflex; 1D pulse wave propagation; IMMEDIATE EXERCISE HYPEREMIA; WAVE-PROPAGATION MODEL; MATHEMATICAL-MODEL; BLOOD-FLOW; INTRACRANIAL-PRESSURE; RAPID VASODILATION; AUTOREGULATION; CIRCULATION; DYNAMICS; HUMANS;

D O I：

10.1016/j.jocs.2017.04.007

中图分类号：

TP39 [计算机的应用];

学科分类号：

081203 ; 0835 ;

摘要：

In this study the regulation of vascular tone inducing the blood flow increase at the onset of exercise is examined. Therefore, our calf circulation model was extended with a regulation model to simulate changes in vascular tone depending on myogenic, metabolic and baroreflex regulation. The simulated blood flow corresponded to the in vivo response and it was concluded that metabolic activation caused the flow increase shortly after muscle contraction. Secondly, the change in baseline flow upon tilt was a result of myogenic and baroreflex activation. Based on a sensitivity analysis the myogenic gain was identified as most important parameter. (C) 2017 Elsevier B.V. All rights reserved.

引用

页码：143 / 159

页数：17

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