Macrophage Signaling Pathways in Pulmonary Nontuberculous Mycobacteria Infections

被引：26

作者：

Prasla, Zohra ^{[1
,2
]}

Sutliff, Roy L. ^{[1
,2
]}

Sadikot, Ruxana T. ^{[1
,2
]}

机构：

[1] Emory Univ, Sch Med, Dept Med, Div Pulm Allergy Crit Care & Sleep Med, Atlanta, GA USA

[2] Atlanta Vet Affairs Hlth Care Syst, Decatur, GA USA

来源：

AMERICAN JOURNAL OF RESPIRATORY CELL AND MOLECULAR BIOLOGY | 2020年 / 63卷 / 02期

基金：

美国国家卫生研究院;

关键词：

macrophage; Mycobacterium avium; Mycobacterium abscessus; autophagy; inflammasome; TOLL-LIKE RECEPTORS; LUNG-DISEASE; IMMUNE-RESPONSE; AVIUM INFECTION; ABSCESSUS; INNATE; PREVALENCE; EPIDEMIOLOGY; SURVIVAL; DEFECTS;

D O I：

10.1165/rcmb.2019-0241TR

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

The incidence and prevalence of nontuberculous mycobacteria (NTM) lung disease is rising worldwide and accounts for most clinical cases of NTM disease. NTM infections occur in both immunocompetent and immunocompromised hosts. Macrophages are the primary host cells that initiate an immune response to NTM. Defining the molecular events that govern the control of infection within macrophages is fundamental to understanding the pathogenesis of NTM disease. Here, we review key macrophage host signaling pathways that contribute to the host immune response to pulmonary NTM infections. In this review, we focus primarily on NTM that are known to cause lung disease, including Mycobacterium avium intracellulare, M. abscessus, and M. kansasii.

引用

页码：144 / 151

页数：8

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