β-Glucan from Aureobasidum species inhibits fat accumulation in 3T3-L1 adipocyte differentiation

被引：2

作者：

Kim, Mi-Ja ^{[1
]}

Kim, Ork-Hee ^{[2
]}

Cheong, Chul ^{[2
]}

Jang, Ki-Hyo ^{[3
]}

Kim, Chul-Ho ^{[4
]}

Kang, Soon Ah ^{[5
]}

机构：

[1] Sungkyunkwan Univ, Coll Biotechnol & Bioengn, Suwon 440746, Gyeonggi, South Korea

[2] Seoul Venture Univ, Dept Fermented Food Sci, Seoul 137070, South Korea

[3] Kangwon Natl Univ, Dept Food & Nutr, Samcheok 245711, Gangwon, South Korea

[4] Korea Res Inst Biosci & Biotechnol, Biotechnol Res Div, Taejon 306809, South Korea

[5] Hoseo Univ, Dept Conversing Technol, Grad Sch Venture, Inst Hlth Ind, Seoul 137867, South Korea

来源：

FOOD SCIENCE AND BIOTECHNOLOGY | 2015年 / 24卷 / 03期

基金：

新加坡国家研究基金会;

关键词：

bacterial derived beta-glucan; 3T3-L1; proliferator-activated receptor gamma; acetyl CoA carboxylase; adipocyte lipid-binding protein; SEPTIC SHOCK; MICE; INDOMETHACIN; CONSUMPTION; METABOLISM; WEIGHT; MODEL; MEN;

D O I：

10.1007/s10068-015-0146-4

中图分类号：

TS2 [食品工业];

学科分类号：

0832 ;

摘要：

The anti-fat accumulative effects of bacteria-derived beta-glucan in 3T3-L1 adipocyte differentiation was investigated. 3T3-L1 preadipocytes were treated with beta-glucan at 50 and 100 mu g/mL during adipogenesis. Oil Red O staining was used to study expressions of the adipogenic genes PPAR gamma, ACC, and aP2. Adipogenesis of 3T3-L1 cells treated with beta-glucan at 50 and 100 mu g/mL was significantly (p < 0.05) inhibited by 32.8 and 39.7%, respectively, compared with controls. Expressions of the PPAR gamma gene from 3T3-L1 cells treated with beta-glucan at 50 and 100 mu g/mL were significantly (p < 0.05) decreased by 13.6 and 46.1%, respectively, ACC gene expression by 18.3 and 36.0%, respectively, and aP2 gene expression by 36.8 and 56.7%, respectively, compared to adipocyte controls. Bacteria-derived beta-glucan inhibits fat accumulation at the cellular level that is mediated via decreases in expressions of the PPAR gamma, ACC, and aP2 genes.

引用

页码：1147 / 1150

页数：4

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