The evolution of hierarchical gene regulatory networks

被引：328

作者：

Erwin, Douglas H. ^{[1
,2
]}

Davidson, Eric H. ^{[3
]}

机构：

[1] Natl Museum Nat Hist, Dept Paleobiol, Washington, DC 20013 USA

[2] Santa Fe Inst, Santa Fe, NM 87501 USA

[3] CALTECH, Div Biol 156 29, Pasadena, CA 91125 USA

来源：

NATURE REVIEWS GENETICS | 2009年 / 10卷 / 02期

基金：

美国国家科学基金会;

关键词：

ACHAETE-SCUTE HOMOLOGS; HOX PROTEIN; PRONEURAL CLUSTERS; PELVIC REDUCTION; IMAGINAL DISC; EVO-DEVO; EXPRESSION; PATTERN; BIOLOGY; MACROEVOLUTION;

D O I：

10.1038/nrg2499

中图分类号：

Q3 [遗传学];

学科分类号：

071007 ; 090102 ;

摘要：

Comparative developmental evidence indicates that reorganizations in developmental gene regulatory networks (GRNs) underlie evolutionary changes in animal morphology, including body plans. We argue here that the nature of the evolutionary alterations that arise from regulatory changes depends on the hierarchical position of the change within a GRN. This concept cannot be accomodated by microevolutionary nor macroevolutionary theory. It will soon be possible to investigate these ideas experimentally, by assessing the effects of GRN changes on morphological evolution.

引用

页码：141 / 148

页数：8

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