Cell density-dependent modulation of perlecan synthesis by dichloro(2,9-dimethyl-1,10-phenanthroline)zinc(II) in vascular endothelial cells

被引：6

作者：

Hara, Takato ^{[1
]}

Sakamaki, Sayaka ^{[1
]}

Ikeda, Atsuya ^{[1
]}

Nakamura, Takehiro ^{[2
]}

Yamamoto, Chika ^{[1
]}

Kaji, Toshiyuki ^{[3
]}

机构：

[1] Toho Univ, Fac Pharmaceut Sci, 2-2-1 Miyama, Funabashi, Chiba 2748510, Japan

[2] Kindai Univ, Fac Pharm, 3-4-1 Kowakae, Higashiosaka, Osaka 5778502, Japan

[3] Tokyo Univ Sci, Fac Pharmaceut Sci, 2641 Yamazaki, Noda, Chiba 2788510, Japan

来源：

JOURNAL OF TOXICOLOGICAL SCIENCES | 2020年 / 45卷 / 02期

关键词：

Bioorganometallics; Proteoglycan; Perlecan; Vascular endothelial cell; Zinc complex; 2,9-Dimethyl-1,10-phenathroline; PROTEOGLYCANS; CYTOTOXICITY;

D O I：

10.2131/jts.45.109

中图分类号：

R99 [毒物学（毒理学）];

学科分类号：

100405 ;

摘要：

Proteoglycans that are synthesized by vascular endothelial cells contribute to the proliferation, migration, and blood coagulation-fibrinolytic system in vascular endothelial cells. Clarification of the molecular mechanisms for proteoglycan synthesis allows understanding of the regulation of endothelial functions. The research strategy of bioorganometallics analyzes biological systems using organic-inorganic hybrid molecules as tools. The present study found dichloro(2,9-dimethyl-1,10-phenanthroline) zinc(II) and its ligand-modulated perlecan expression in vascular endothelial cells, which depends on the cell density.

引用

页码：109 / 115

页数：7

共 16 条

[1] Possible mechanisms underlying transcriptional induction of metallothionein isoforms by tris(pentafluorophenyl) stibane, tris(pentafluorophenyl)arsane, and tris(pentafluorophenyl)phosphane in cultured bovine aortic endothelial cells [J].

Fujie, Tomoya ;

Takenaka, Fukuta ;

Yoshida, Eiko ;

Yasuike, Shuji ;

Fujiwara, Yasuyuki ;

Shinkai, Yasuhiro ;

Kumagai, Yoshito ;

Yamamoto, Chika ;

Kaji, Toshiyuki .

JOURNAL OF TOXICOLOGICAL SCIENCES, 2019, 44 (4-6) :327-333

[2]

Fujie Tomoya, 2016, J Toxicol Sci, V41, pSP81, DOI 10.2131/jts.41.SP81

[3]

Hara T., 2016, Fundam. Toxicol. Sci, V3, P109, DOI [10.2131/fts.3.109, DOI 10.2131/FTS.3.109]

[4] Intracellular accumulation-independent cytotoxicity of pentavalent organoantimony compounds in cultured vascular endothelial cells [J].

Hara, Takato ;

Nakano, Shihoko ;

Kitamura, Yuki ;

Yamamoto, Chika ;

Yasuike, Shuji ;

Kaji, Toshiyuki .

JOURNAL OF TOXICOLOGICAL SCIENCES, 2019, 44 (10-12) :845-848

[5] Copper(II) Bis(diethyldithiocarbamate) Induces the Expression of Syndecan-4, a Transmembrane Heparan Sulfate Proteoglycan, via p38 MAPK Activation in Vascular Endothelial Cells [J].

Hara, Takato ;

Tatsuishi, Hiroko ;

Banno, Tomomi ;

Fujie, Tomoya ;

Yamamoto, Chika ;

Naka, Hiroshi ;

Kaji, Toshiyuki .

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES, 2018, 19 (11)

[6] Transforming Growth Factor-1 Modulates the Expression of Syndecan-4 in Cultured Vascular Endothelial Cells in a Biphasic Manner [J].

Hara, Takato ;

Yoshida, Eiko ;

Fujiwara, Yasuyuki ;

Yamamoto, Chika ;

Kaji, Toshiyuki .

JOURNAL OF CELLULAR BIOCHEMISTRY, 2017, 118 (08) :2009-2017

[7] Induction of Syndecan-4 by Organic-Inorganic Hybrid Molecules with a 1,10-Phenanthroline Structure in Cultured Vascular Endothelial Cells [J].

Hara, Takato ;

Kojima, Takayuki ;

Matsuzaki, Hiroka ;

Nakamura, Takehiro ;

Yoshida, Eiko ;

Fujiwara, Yasuyuki ;

Yamamoto, Chika ;

Saito, Shinichi ;

Kaji, Toshiyuki .

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES, 2017, 18 (02)

[8] Biglycan Intensifies ALK5-Smad2/3 Signaling by TGF-1 and Downregulates Syndecan-4 in Cultured Vascular Endothelial Cells [J].

Hara, Takato ;

Yoshida, Eiko ;

Shinkai, Yasuhiro ;

Yamamoto, Chika ;

Fujiwara, Yasuyuki ;

Kumagai, Yoshito ;

Kaji, Toshiyuki .

JOURNAL OF CELLULAR BIOCHEMISTRY, 2017, 118 (05) :1087-1096

[9] Cell density-dependent regulation of proteoglycan synthesis by transforming growth factor-β1 in cultured bovine aortic endothelial cells [J].

Kaji, T ;

Yamada, A ;

Miyajima, S ;

Yamamoto, C ;

Fujiwara, Y ;

Wight, TN ;

Kinsella, MG .

JOURNAL OF BIOLOGICAL CHEMISTRY, 2000, 275 (02) :1463-1470

[10] The vascular endothelial growth factor VEGF165 induces perlecan synthesis via VEGF receptor-2 in cultured human brain microvascular endothelial cells [J].

Kaji, Toshiyuki ;

Yamamoto, Chika ;

Oh-i, Mami ;

Fujiwara, Yasuyuki ;

Yamazaki, Yasuo ;

Morita, Takashi ;

Plaas, Anna H. ;

Wight, Thomas N. .

BIOCHIMICA ET BIOPHYSICA ACTA-GENERAL SUBJECTS, 2006, 1760 (09) :1465-1474

← 1 2 →