Cu(II)-catalyzed highly regio- and stereoselective construction of C-C double bonds: an efficient method for the ketonization-olefination of indoles

被引：22

作者：

Bao, Yun-Hong ^{[1
]}

Zhu, Jia-Yi ^{[1
]}

Qin, Wen-Bing ^{[1
]}

Kong, Yu-Bo ^{[1
]}

Chen, Zheng-Wang ^{[1
]}

Tang, Shao-Bin ^{[1
]}

Liu, Liang-Xian ^{[1
]}

机构：

[1] Gannan Normal Univ, Dept Chem & Chem Engn, Ganzhou 341000, Jiangxi, Peoples R China

来源：

ORGANIC & BIOMOLECULAR CHEMISTRY | 2013年 / 11卷 / 45期

关键词：

CATALYZED OXIDATIVE TRIMERIZATION; MOLECULAR-OXYGEN; TEMPO; FUNCTIONALIZATION; ALKALOIDS; ACCESS; ACID; AIR;

D O I：

10.1039/c3ob41589a

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

A general and efficient method for the cross-coupling of indoles with beta-keto esters by using TEMPO/CuSO4 center dot 5H(2)O in air as oxidant has been developed. This reaction features high functional-group compatibility and an excellent selectivity. This methodology provides an alternative approach for the ketonization-olefination of indoles in moderate to good yields.

引用

页码：7938 / 7945

页数：8

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