The ε4 Allele of the APOE Gene Is Associated With More Severe Peripheral Neuropathy in Type 2 Diabetic Patients

被引：20

作者：

Monastiriotis, C. ^{[1
]}

Papanas, N. ^{[1
]}

Trypsianis, G. ^{[2
]}

Karanikola, K. ^{[3
]}

Veletza, S. ^{[3
]}

Maltezos, E. ^{[1
]}

机构：

[1] Democritus Univ Thrace, Dept Internal Med 2, Outpatient Clin Diabet Foot, Alexandroupolis 68100, Greece

[2] Democritus Univ Thrace, Sch Med, Dept Med Stat, Alexandroupolis 68100, Greece

[3] Democritus Univ Thrace, Sch Med, Med Biol Lab, Alexandroupolis 68100, Greece

来源：

ANGIOLOGY | 2013年 / 64卷 / 06期

关键词：

apolipoprotein E; diabetes mellitus; diabetic neuropathy; genes; polymorphisms; APOLIPOPROTEIN-E POLYMORPHISM; RISK-FACTORS; DISEASE; NERVE; ONSET; GENOTYPE; PROTEIN; FOOT; THRESHOLD; FREQUENCY;

D O I：

10.1177/0003319712453645

中图分类号：

R6 [外科学];

学科分类号：

1002 ; 100210 ;

摘要：

We examined the association between the 4 allele of the apolipoprotein E gene and severity of peripheral neuropathy in 234 patients with type 2 diabetes mellitus (T2DM). Based on the Neuropathy Disability Score (NDS), patients were divided into group A (NDS 6: mild or no neuropathy) and group B (NDS >6: severe neuropathy). In each group, patients were further divided into 4 carriers and non-4 carriers. In multivariate analysis, a more than 5-fold increased risk of severe neuropathy was associated with 4 carrier status (adjusted odds ratio [aOR]: 5.26, 95% confidence interval [CI]: 2.24-12.31, P = .0001). The other significant risk factors for severe neuropathy included male gender (aOR: 2.08, 95% CI: 1.05-4.14, P = .036), diabetes duration (aOR: 1.05, 95% CI: 1.00-1.09, P = .039), and hemoglobin A(1c) (aOR: 1.32, 95% CI: 1.05-1.66, P = .020). In conclusion, the 4 carrier status appears to be associated with severe peripheral neuropathy in T2DM.

引用

页码：451 / 455

页数：5

共 47 条

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