Energy balance regulation by thyroid hormones at central level

被引：154

作者：

Lopez, Miguel ^{[1
,2
]}

Alvarez, Clara V. ^{[1
]}

Nogueiras, Ruben ^{[1
,2
]}

Dieguez, Carlos ^{[1
,2
]}

机构：

[1] Univ Santiago de Compostela, Inst Invest Sanitaria, CIMUS, Dept Physiol, Santiago De Compostela 15782, Spain

[2] CIBER Fisiopatol Obesidad & Nutr CIBERobn, Santiago De Compostela 15706, Spain

来源：

TRENDS IN MOLECULAR MEDICINE | 2013年 / 19卷 / 07期

基金：

欧洲研究理事会;

关键词：

thyroid hormones; central nervous system; hypothalamus; energy balance; lipid metabolism; glucose homeostasis; BROWN ADIPOSE-TISSUE; RECEPTOR-ALPHA GENE; INDUCED INSULIN-RESISTANCE; ACTIVATED PROTEIN-KINASE; MESSENGER-RNA LEVELS; BASAL METABOLIC-RATE; SKELETAL-MUSCLE; FOOD-INTAKE; ADAPTIVE THERMOGENESIS; HUMAN HYPOTHALAMUS;

D O I：

10.1016/j.molmed.2013.04.004

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Classically, medical textbooks taught that most effects of thyroid hormones (THs) on energy homeostasis are directly exerted in peripheral tissues. However, current evidence is changing (and challenging) our perspective about the role of THs from a 'peripheral' to a 'central' vision, implying that they affect food intake, energy expenditure, and metabolism by acting, to a large extent, at the central level. Interestingly, effects of THs are interrelated with global energy sensors in the central nervous system (CNS), such as uncoupling protein 2 (UCP2), AMP-activated protein kinase (AMPK; the 'AMPK-BAT axis'), and mechanistic target of rapamycin (mTOR). Here, we review what is currently known about THs and their regulation of energy balance and metabolism in both peripheral and central tissues.

引用

页码：418 / 427

页数：10

共 94 条

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