SYNTHESIS AND BIOLOGICAL EVALUATION OF ACYCLIC PHOSPHONIC ACID NUCLEOSIDE DERIVATIVES

被引：2

作者：

Wainwright, Philip ^{[1
]}

Maddaford, Adrian ^{[1
]}

Zhang, Xiurong ^{[1
]}

Billington, Helen ^{[1
]}

Leese, David ^{[1
]}

Glen, Rebecca ^{[1
]}

Pryde, David C. ^{[2
]}

Middleton, Donald S. ^{[2
]}

Stephenson, Peter T. ^{[2
]}

Sutton, Scott ^{[3
]}

机构：

[1] Peakdale Mol Ltd, Chapel En Le Frith SK23 0PG, Derby, England

[2] Pfizer Neusentis, Worldwide Med Chem, Cambridge, England

[3] Pfizer Global Res & Dev, San Diego, CA USA

来源：

NUCLEOSIDES NUCLEOTIDES & NUCLEIC ACIDS | 2013年 / 32卷 / 09期

关键词：

Antivirals; acyclic phosphonic acid nucleosides;

D O I：

10.1080/15257770.2013.820833

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

As part of a project to generate a library of nucleosides as potential antiviral agents, a small subset of novel acyclic phosphonic acid nucleosides was prepared. Practical synthetic routes are described for three targets, which were then tested against HIV, hepatitis C virus (HCV), and Dengue virus.

引用

页码：477 / 492

页数：16

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