共 50 条
[41]
The Evolution of Human Segmental Duplications and the Core Duplicon Hypothesis
[J].
Marques-Bonet, T.
;
Eichler, E. E.
.
EVOLUTION: THE MOLECULAR LANDSCAPE,
2009, 74
:355-362

Marques-Bonet, T.
论文数: 0 引用数: 0
h-index: 0
机构:
Univ Washington, Dept Genome Sci, Seattle, WA 98195 USA
UPF, Inst Biol Evolut, CSIC, Barcelona 08003, Catalonia, Spain Univ Washington, Dept Genome Sci, Seattle, WA 98195 USA

Eichler, E. E.
论文数: 0 引用数: 0
h-index: 0
机构:
Univ Washington, Dept Genome Sci, Seattle, WA 98195 USA
Howard Hughes Med Inst, Seattle, WA 98195 USA Univ Washington, Dept Genome Sci, Seattle, WA 98195 USA
[42]
Segmental Duplications in Subtelomeric Regions of Human Chromosome 13
[J].
N. S. Kupriyanova
;
D. V. Shibalev
;
A. S. Voronov
;
O. V. Muravenko
;
A. V. Zelenin
;
A. P. Ryskov
.
Molecular Biology,
2003, 37
:194-199

N. S. Kupriyanova
论文数: 0 引用数: 0
h-index: 0
机构: Russian Academy of Sciences,Institute of Gene Biology

D. V. Shibalev
论文数: 0 引用数: 0
h-index: 0
机构: Russian Academy of Sciences,Institute of Gene Biology

A. S. Voronov
论文数: 0 引用数: 0
h-index: 0
机构: Russian Academy of Sciences,Institute of Gene Biology

O. V. Muravenko
论文数: 0 引用数: 0
h-index: 0
机构: Russian Academy of Sciences,Institute of Gene Biology

A. V. Zelenin
论文数: 0 引用数: 0
h-index: 0
机构: Russian Academy of Sciences,Institute of Gene Biology

A. P. Ryskov
论文数: 0 引用数: 0
h-index: 0
机构: Russian Academy of Sciences,Institute of Gene Biology
[43]
Identification of human haploinsufficient genes and their genomic proximity to segmental duplications
[J].
Dang, Vinh T.
;
Kassahn, Karin S.
;
Marcos, Andres Esteban
;
Ragan, Mark A.
.
EUROPEAN JOURNAL OF HUMAN GENETICS,
2008, 16 (11)
:1350-1357

Dang, Vinh T.
论文数: 0 引用数: 0
h-index: 0
机构:
Univ Queensland, Inst Mol Biosci, Brisbane, Qld 4072, Australia
ARC Ctr Excellence Bioinformat, Brisbane, Qld, Australia Univ Queensland, Inst Mol Biosci, Brisbane, Qld 4072, Australia

Kassahn, Karin S.
论文数: 0 引用数: 0
h-index: 0
机构:
Univ Queensland, Inst Mol Biosci, Brisbane, Qld 4072, Australia
ARC Ctr Excellence Bioinformat, Brisbane, Qld, Australia Univ Queensland, Inst Mol Biosci, Brisbane, Qld 4072, Australia

Marcos, Andres Esteban
论文数: 0 引用数: 0
h-index: 0
机构:
Univ Queensland, Inst Mol Biosci, Brisbane, Qld 4072, Australia
ARC Ctr Excellence Bioinformat, Brisbane, Qld, Australia Univ Queensland, Inst Mol Biosci, Brisbane, Qld 4072, Australia

Ragan, Mark A.
论文数: 0 引用数: 0
h-index: 0
机构:
Univ Queensland, Inst Mol Biosci, Brisbane, Qld 4072, Australia
ARC Ctr Excellence Bioinformat, Brisbane, Qld, Australia Univ Queensland, Inst Mol Biosci, Brisbane, Qld 4072, Australia
[44]
Identification of human haploinsufficient genes and their genomic proximity to segmental duplications
[J].
Vinh T Dang
;
Karin S Kassahn
;
Andrés Esteban Marcos
;
Mark A Ragan
.
European Journal of Human Genetics,
2008, 16
:1350-1357

Vinh T Dang
论文数: 0 引用数: 0
h-index: 0
机构: ARC Centre of Excellence in Bioinformatics,

Karin S Kassahn
论文数: 0 引用数: 0
h-index: 0
机构: ARC Centre of Excellence in Bioinformatics,

Andrés Esteban Marcos
论文数: 0 引用数: 0
h-index: 0
机构: ARC Centre of Excellence in Bioinformatics,

Mark A Ragan
论文数: 0 引用数: 0
h-index: 0
机构: ARC Centre of Excellence in Bioinformatics,
[45]
The evolution and population diversity of human-specific segmental duplications
[J].
Dennis, Megan Y.
;
Harshman, Lana
;
Nelson, Bradley J.
;
Penn, Osnat
;
Cantsilieris, Stuart
;
Huddleston, John
;
Antonacci, Francesca
;
Penewit, Kelsi
;
Denman, Laura
;
Raja, Archana
;
Baker, Carl
;
Mark, Kenneth
;
Malig, Maika
;
Janke, Nicolette
;
Espinoza, Claudia
;
Stessman, Holly A. F.
;
Nuttle, Xander
;
Hoekzema, Kendra
;
Lindsay-Graves, Tina A.
;
Wilson, Richard K.
;
Eichler, Evan E.
.
NATURE ECOLOGY & EVOLUTION,
2017, 1 (03)

Dennis, Megan Y.
论文数: 0 引用数: 0
h-index: 0
机构:
Univ Calif Davis, MIND Inst, Genome Ctr, Davis, CA 95616 USA
Univ Calif Davis, Dept Biochem & Mol Med, Davis, CA 95616 USA
Univ Washington, Sch Med, Dept Genome Sci, Seattle, WA 98195 USA Univ Calif Davis, MIND Inst, Genome Ctr, Davis, CA 95616 USA

Harshman, Lana
论文数: 0 引用数: 0
h-index: 0
机构:
Univ Washington, Sch Med, Dept Genome Sci, Seattle, WA 98195 USA Univ Calif Davis, MIND Inst, Genome Ctr, Davis, CA 95616 USA

Nelson, Bradley J.
论文数: 0 引用数: 0
h-index: 0
机构:
Univ Washington, Sch Med, Dept Genome Sci, Seattle, WA 98195 USA Univ Calif Davis, MIND Inst, Genome Ctr, Davis, CA 95616 USA

Penn, Osnat
论文数: 0 引用数: 0
h-index: 0
机构:
Univ Washington, Sch Med, Dept Genome Sci, Seattle, WA 98195 USA Univ Calif Davis, MIND Inst, Genome Ctr, Davis, CA 95616 USA

Cantsilieris, Stuart
论文数: 0 引用数: 0
h-index: 0
机构:
Univ Washington, Sch Med, Dept Genome Sci, Seattle, WA 98195 USA Univ Calif Davis, MIND Inst, Genome Ctr, Davis, CA 95616 USA

Huddleston, John
论文数: 0 引用数: 0
h-index: 0
机构:
Univ Washington, Sch Med, Dept Genome Sci, Seattle, WA 98195 USA
Univ Washington, Howard Hughes Med Inst, Seattle, WA 98195 USA Univ Calif Davis, MIND Inst, Genome Ctr, Davis, CA 95616 USA

论文数: 引用数:
h-index:
机构:

Penewit, Kelsi
论文数: 0 引用数: 0
h-index: 0
机构:
Univ Washington, Sch Med, Dept Genome Sci, Seattle, WA 98195 USA Univ Calif Davis, MIND Inst, Genome Ctr, Davis, CA 95616 USA

Denman, Laura
论文数: 0 引用数: 0
h-index: 0
机构:
Univ Washington, Sch Med, Dept Genome Sci, Seattle, WA 98195 USA Univ Calif Davis, MIND Inst, Genome Ctr, Davis, CA 95616 USA

Raja, Archana
论文数: 0 引用数: 0
h-index: 0
机构:
Univ Washington, Sch Med, Dept Genome Sci, Seattle, WA 98195 USA
Univ Washington, Howard Hughes Med Inst, Seattle, WA 98195 USA Univ Calif Davis, MIND Inst, Genome Ctr, Davis, CA 95616 USA

Baker, Carl
论文数: 0 引用数: 0
h-index: 0
机构:
Univ Washington, Sch Med, Dept Genome Sci, Seattle, WA 98195 USA Univ Calif Davis, MIND Inst, Genome Ctr, Davis, CA 95616 USA

Mark, Kenneth
论文数: 0 引用数: 0
h-index: 0
机构:
Univ Washington, Sch Med, Dept Genome Sci, Seattle, WA 98195 USA Univ Calif Davis, MIND Inst, Genome Ctr, Davis, CA 95616 USA

Malig, Maika
论文数: 0 引用数: 0
h-index: 0
机构:
Univ Washington, Sch Med, Dept Genome Sci, Seattle, WA 98195 USA Univ Calif Davis, MIND Inst, Genome Ctr, Davis, CA 95616 USA

Janke, Nicolette
论文数: 0 引用数: 0
h-index: 0
机构:
Univ Washington, Sch Med, Dept Genome Sci, Seattle, WA 98195 USA Univ Calif Davis, MIND Inst, Genome Ctr, Davis, CA 95616 USA

Espinoza, Claudia
论文数: 0 引用数: 0
h-index: 0
机构:
Univ Washington, Sch Med, Dept Genome Sci, Seattle, WA 98195 USA Univ Calif Davis, MIND Inst, Genome Ctr, Davis, CA 95616 USA

Stessman, Holly A. F.
论文数: 0 引用数: 0
h-index: 0
机构:
Univ Washington, Sch Med, Dept Genome Sci, Seattle, WA 98195 USA Univ Calif Davis, MIND Inst, Genome Ctr, Davis, CA 95616 USA

Nuttle, Xander
论文数: 0 引用数: 0
h-index: 0
机构:
Univ Washington, Sch Med, Dept Genome Sci, Seattle, WA 98195 USA Univ Calif Davis, MIND Inst, Genome Ctr, Davis, CA 95616 USA

Hoekzema, Kendra
论文数: 0 引用数: 0
h-index: 0
机构:
Univ Washington, Sch Med, Dept Genome Sci, Seattle, WA 98195 USA Univ Calif Davis, MIND Inst, Genome Ctr, Davis, CA 95616 USA

Lindsay-Graves, Tina A.
论文数: 0 引用数: 0
h-index: 0
机构:
Washington Univ, Sch Med, McDonnell Genome Inst, St Louis, MO 63108 USA Univ Calif Davis, MIND Inst, Genome Ctr, Davis, CA 95616 USA

Wilson, Richard K.
论文数: 0 引用数: 0
h-index: 0
机构:
Washington Univ, Sch Med, McDonnell Genome Inst, St Louis, MO 63108 USA Univ Calif Davis, MIND Inst, Genome Ctr, Davis, CA 95616 USA

Eichler, Evan E.
论文数: 0 引用数: 0
h-index: 0
机构:
Univ Washington, Sch Med, Dept Genome Sci, Seattle, WA 98195 USA
Univ Washington, Howard Hughes Med Inst, Seattle, WA 98195 USA Univ Calif Davis, MIND Inst, Genome Ctr, Davis, CA 95616 USA
[46]
Circular DNA intermediates in the generation of large human segmental duplications
[J].
Javier U. Chicote
;
Marcos López-Sánchez
;
Tomàs Marquès-Bonet
;
José Callizo
;
Luis A. Pérez-Jurado
;
Antonio García-España
.
BMC Genomics,
21

Javier U. Chicote
论文数: 0 引用数: 0
h-index: 0
机构: Hospital Universitari de Tarragona Joan XXIII,Research Unit

Marcos López-Sánchez
论文数: 0 引用数: 0
h-index: 0
机构: Hospital Universitari de Tarragona Joan XXIII,Research Unit

Tomàs Marquès-Bonet
论文数: 0 引用数: 0
h-index: 0
机构: Hospital Universitari de Tarragona Joan XXIII,Research Unit

José Callizo
论文数: 0 引用数: 0
h-index: 0
机构: Hospital Universitari de Tarragona Joan XXIII,Research Unit

Luis A. Pérez-Jurado
论文数: 0 引用数: 0
h-index: 0
机构: Hospital Universitari de Tarragona Joan XXIII,Research Unit

Antonio García-España
论文数: 0 引用数: 0
h-index: 0
机构: Hospital Universitari de Tarragona Joan XXIII,Research Unit
[47]
Interchromosomal segmental duplications of the pericentromeric region on the human Y chromosome
[J].
Kirsch, S
;
Weiss, B
;
Miner, TL
;
Waterston, RH
;
Clark, RA
;
Eichler, EE
;
Münch, C
;
Schempp, W
;
Rappold, G
.
GENOME RESEARCH,
2005, 15 (02)
:195-204

Kirsch, S
论文数: 0 引用数: 0
h-index: 0
机构: Heidelberg Univ, Inst Human Genet, D-69120 Heidelberg, Germany

Weiss, B
论文数: 0 引用数: 0
h-index: 0
机构: Heidelberg Univ, Inst Human Genet, D-69120 Heidelberg, Germany

Miner, TL
论文数: 0 引用数: 0
h-index: 0
机构: Heidelberg Univ, Inst Human Genet, D-69120 Heidelberg, Germany

Waterston, RH
论文数: 0 引用数: 0
h-index: 0
机构: Heidelberg Univ, Inst Human Genet, D-69120 Heidelberg, Germany

Clark, RA
论文数: 0 引用数: 0
h-index: 0
机构: Heidelberg Univ, Inst Human Genet, D-69120 Heidelberg, Germany

Eichler, EE
论文数: 0 引用数: 0
h-index: 0
机构: Heidelberg Univ, Inst Human Genet, D-69120 Heidelberg, Germany

Münch, C
论文数: 0 引用数: 0
h-index: 0
机构: Heidelberg Univ, Inst Human Genet, D-69120 Heidelberg, Germany

Schempp, W
论文数: 0 引用数: 0
h-index: 0
机构: Heidelberg Univ, Inst Human Genet, D-69120 Heidelberg, Germany

Rappold, G
论文数: 0 引用数: 0
h-index: 0
机构: Heidelberg Univ, Inst Human Genet, D-69120 Heidelberg, Germany
[48]
Increased mutation and gene conversion within human segmental duplications
[J].
Vollger, Mitchell R.
;
Dishuck, Philip C.
;
Harvey, William T.
;
DeWitt, William S.
;
Guitart, Xavi
;
Goldberg, Michael E.
;
Rozanski, Allison N.
;
Lucas, Julian
;
Asri, Mobin
;
Munson, Katherine M.
;
Lewis, Alexandra P.
;
Hoekzema, Kendra
;
Logsdon, Glennis A.
;
Porubsky, David
;
Paten, Benedict
;
Harris, Kelley
;
Hsieh, PingHsun
;
Eichler, Evan E.
.
NATURE,
2023, 617 (7960)
:325-334

Vollger, Mitchell R.
论文数: 0 引用数: 0
h-index: 0
机构:
Univ Washington, Dept Genome Sci, Sch Med, Seattle, WA 98195 USA
Univ Washington, Sch Med, Div Med Genet, Seattle, WA 98195 USA Univ Washington, Dept Genome Sci, Sch Med, Seattle, WA 98195 USA

Dishuck, Philip C.
论文数: 0 引用数: 0
h-index: 0
机构:
Univ Washington, Dept Genome Sci, Sch Med, Seattle, WA 98195 USA Univ Washington, Dept Genome Sci, Sch Med, Seattle, WA 98195 USA

Harvey, William T.
论文数: 0 引用数: 0
h-index: 0
机构:
Univ Washington, Dept Genome Sci, Sch Med, Seattle, WA 98195 USA Univ Washington, Dept Genome Sci, Sch Med, Seattle, WA 98195 USA

DeWitt, William S.
论文数: 0 引用数: 0
h-index: 0
机构:
Univ Washington, Dept Genome Sci, Sch Med, Seattle, WA 98195 USA
Fred Hutchinson Canc Res Ctr, Computat Biol Program, Seattle, WA USA
Univ Calif Berkeley, Dept Elect Engn & Comp Sci, Berkeley, CA USA Univ Washington, Dept Genome Sci, Sch Med, Seattle, WA 98195 USA

论文数: 引用数:
h-index:
机构:

Goldberg, Michael E.
论文数: 0 引用数: 0
h-index: 0
机构:
Univ Washington, Dept Genome Sci, Sch Med, Seattle, WA 98195 USA Univ Washington, Dept Genome Sci, Sch Med, Seattle, WA 98195 USA

Rozanski, Allison N.
论文数: 0 引用数: 0
h-index: 0
机构:
Univ Washington, Dept Genome Sci, Sch Med, Seattle, WA 98195 USA Univ Washington, Dept Genome Sci, Sch Med, Seattle, WA 98195 USA

Lucas, Julian
论文数: 0 引用数: 0
h-index: 0
机构:
Univ Calif Santa Cruz, UC Santa Cruz Genom Inst, Santa Cruz, CA USA Univ Washington, Dept Genome Sci, Sch Med, Seattle, WA 98195 USA

Asri, Mobin
论文数: 0 引用数: 0
h-index: 0
机构:
Univ Calif Santa Cruz, UC Santa Cruz Genom Inst, Santa Cruz, CA USA Univ Washington, Dept Genome Sci, Sch Med, Seattle, WA 98195 USA

Munson, Katherine M.
论文数: 0 引用数: 0
h-index: 0
机构:
Univ Washington, Dept Genome Sci, Sch Med, Seattle, WA 98195 USA Univ Washington, Dept Genome Sci, Sch Med, Seattle, WA 98195 USA

Lewis, Alexandra P.
论文数: 0 引用数: 0
h-index: 0
机构:
Univ Washington, Dept Genome Sci, Sch Med, Seattle, WA 98195 USA Univ Washington, Dept Genome Sci, Sch Med, Seattle, WA 98195 USA

Hoekzema, Kendra
论文数: 0 引用数: 0
h-index: 0
机构:
Univ Washington, Dept Genome Sci, Sch Med, Seattle, WA 98195 USA Univ Washington, Dept Genome Sci, Sch Med, Seattle, WA 98195 USA

Logsdon, Glennis A.
论文数: 0 引用数: 0
h-index: 0
机构:
Univ Washington, Dept Genome Sci, Sch Med, Seattle, WA 98195 USA Univ Washington, Dept Genome Sci, Sch Med, Seattle, WA 98195 USA

Porubsky, David
论文数: 0 引用数: 0
h-index: 0
机构:
Univ Washington, Dept Genome Sci, Sch Med, Seattle, WA 98195 USA Univ Washington, Dept Genome Sci, Sch Med, Seattle, WA 98195 USA

Paten, Benedict
论文数: 0 引用数: 0
h-index: 0
机构:
Univ Calif Santa Cruz, UC Santa Cruz Genom Inst, Santa Cruz, CA USA Univ Washington, Dept Genome Sci, Sch Med, Seattle, WA 98195 USA

Harris, Kelley
论文数: 0 引用数: 0
h-index: 0
机构:
Univ Washington, Dept Genome Sci, Sch Med, Seattle, WA 98195 USA Univ Washington, Dept Genome Sci, Sch Med, Seattle, WA 98195 USA

Hsieh, PingHsun
论文数: 0 引用数: 0
h-index: 0
机构:
Univ Washington, Dept Genome Sci, Sch Med, Seattle, WA 98195 USA Univ Washington, Dept Genome Sci, Sch Med, Seattle, WA 98195 USA

Eichler, Evan E.
论文数: 0 引用数: 0
h-index: 0
机构:
Univ Washington, Dept Genome Sci, Sch Med, Seattle, WA 98195 USA
Howard Hughes Med Inst, Chevy Chase, NY 20815 USA Univ Washington, Dept Genome Sci, Sch Med, Seattle, WA 98195 USA
[49]
Segmental duplications in the human genome reveal details of pseudogene formation
[J].
Khurana, Ekta
;
Lam, Hugo Y. K.
;
Cheng, Chao
;
Carriero, Nicholas
;
Cayting, Philip
;
Gerstein, Mark B.
.
NUCLEIC ACIDS RESEARCH,
2010, 38 (20)
:6997-7007

Khurana, Ekta
论文数: 0 引用数: 0
h-index: 0
机构:
Yale Univ, Program Computat Biol & Bioinformat, New Haven, CT 06520 USA
Yale Univ, Dept Mol Biophys & Biochem, New Haven, CT USA Yale Univ, Program Computat Biol & Bioinformat, New Haven, CT 06520 USA

Lam, Hugo Y. K.
论文数: 0 引用数: 0
h-index: 0
机构:
Yale Univ, Program Computat Biol & Bioinformat, New Haven, CT 06520 USA
Stanford Univ, Sch Med, Dept Genet, Stanford, CA 94305 USA Yale Univ, Program Computat Biol & Bioinformat, New Haven, CT 06520 USA

Cheng, Chao
论文数: 0 引用数: 0
h-index: 0
机构:
Yale Univ, Dept Mol Biophys & Biochem, New Haven, CT USA Yale Univ, Program Computat Biol & Bioinformat, New Haven, CT 06520 USA

Carriero, Nicholas
论文数: 0 引用数: 0
h-index: 0
机构:
Yale Univ, Dept Comp Sci, New Haven, CT 06520 USA Yale Univ, Program Computat Biol & Bioinformat, New Haven, CT 06520 USA

Cayting, Philip
论文数: 0 引用数: 0
h-index: 0
机构:
Yale Univ, Dept Mol Biophys & Biochem, New Haven, CT USA
Stanford Univ, Sch Med, Dept Genet, Stanford, CA 94305 USA Yale Univ, Program Computat Biol & Bioinformat, New Haven, CT 06520 USA

Gerstein, Mark B.
论文数: 0 引用数: 0
h-index: 0
机构:
Yale Univ, Program Computat Biol & Bioinformat, New Haven, CT 06520 USA
Yale Univ, Dept Mol Biophys & Biochem, New Haven, CT USA
Yale Univ, Dept Comp Sci, New Haven, CT 06520 USA Yale Univ, Program Computat Biol & Bioinformat, New Haven, CT 06520 USA
[50]
Segmental duplications and copy-number variation in the human genome
[J].
Sharp, AJ
;
Locke, DP
;
McGrath, SD
;
Cheng, Z
;
Bailey, JA
;
Vallente, RU
;
Pertz, LM
;
Clark, RA
;
Schwartz, S
;
Segraves, R
;
Oseroff, VV
;
Albertson, DG
;
Pinkel, D
;
Eichler, EE
.
AMERICAN JOURNAL OF HUMAN GENETICS,
2005, 77 (01)
:78-88

Sharp, AJ
论文数: 0 引用数: 0
h-index: 0
机构: Univ Washington, Dept Genome Sci, Sch Med, Seattle, WA 98195 USA

Locke, DP
论文数: 0 引用数: 0
h-index: 0
机构: Univ Washington, Dept Genome Sci, Sch Med, Seattle, WA 98195 USA

McGrath, SD
论文数: 0 引用数: 0
h-index: 0
机构: Univ Washington, Dept Genome Sci, Sch Med, Seattle, WA 98195 USA

Cheng, Z
论文数: 0 引用数: 0
h-index: 0
机构: Univ Washington, Dept Genome Sci, Sch Med, Seattle, WA 98195 USA

Bailey, JA
论文数: 0 引用数: 0
h-index: 0
机构: Univ Washington, Dept Genome Sci, Sch Med, Seattle, WA 98195 USA

Vallente, RU
论文数: 0 引用数: 0
h-index: 0
机构: Univ Washington, Dept Genome Sci, Sch Med, Seattle, WA 98195 USA

Pertz, LM
论文数: 0 引用数: 0
h-index: 0
机构: Univ Washington, Dept Genome Sci, Sch Med, Seattle, WA 98195 USA

Clark, RA
论文数: 0 引用数: 0
h-index: 0
机构: Univ Washington, Dept Genome Sci, Sch Med, Seattle, WA 98195 USA

Schwartz, S
论文数: 0 引用数: 0
h-index: 0
机构: Univ Washington, Dept Genome Sci, Sch Med, Seattle, WA 98195 USA

Segraves, R
论文数: 0 引用数: 0
h-index: 0
机构: Univ Washington, Dept Genome Sci, Sch Med, Seattle, WA 98195 USA

Oseroff, VV
论文数: 0 引用数: 0
h-index: 0
机构: Univ Washington, Dept Genome Sci, Sch Med, Seattle, WA 98195 USA

Albertson, DG
论文数: 0 引用数: 0
h-index: 0
机构: Univ Washington, Dept Genome Sci, Sch Med, Seattle, WA 98195 USA

Pinkel, D
论文数: 0 引用数: 0
h-index: 0
机构: Univ Washington, Dept Genome Sci, Sch Med, Seattle, WA 98195 USA

Eichler, EE
论文数: 0 引用数: 0
h-index: 0
机构: Univ Washington, Dept Genome Sci, Sch Med, Seattle, WA 98195 USA