Phytochemical analyses and effects of Alchemilla mollis (Buser) Rothm. and Alchemilla persica Rothm. in rat endometriosis model

被引：27

作者：

Akkol, Esra Kupeli ^{[1
]}

Demirel, Murside Ayse ^{[2
]}

Acikara, Ozlem Bahadir ^{[3
]}

Suntar, Ipek ^{[1
]}

Ergene, Burcin ^{[3
]}

Ilhan, Mert ^{[1
]}

Ozbilgin, Serkan ^{[3
]}

Saltan, Gulcin ^{[3
]}

Keles, Hikmet ^{[4
]}

Tekin, Mehmet ^{[5
]}

机构：

[1] Gazi Univ, Dept Pharmacognosy, Fac Pharm, TR-06330 Ankara, Turkey

[2] Gazi Univ, Lab Anim Breeding & Expt Res Ctr, Fac Pharm, TR-06330 Ankara, Turkey

[3] Ankara Univ, Dept Pharmacognosy, Fac Pharm, TR-06100 Tandogan, Turkey

[4] Afyon Kocatepe Univ, Dept Pathol, Fac Vet Med, TR-03200 Afyon, Turkey

[5] Cumhuriyet Univ, Dept Biol, Fac Sci, TR-58140 Sivas, Turkey

来源：

ARCHIVES OF GYNECOLOGY AND OBSTETRICS | 2015年 / 292卷 / 03期

关键词：

Alchemilla mollis; Alchemilla persica; Cytokine; Endometriosis; Phenolic constituent; Rat; Rosaceae; MEDICINAL HERBS; ETHNOPHARMACOLOGICAL SURVEY; ANTIMUTAGENIC PROPERTIES; FLAVONOID GLYCOSIDES; SCAVENGING ACTIVITY; PLANT-EXTRACTS; IN-VITRO; XANTHOCHLORA; VULGARIS; REGION;

D O I：

10.1007/s00404-015-3665-6

中图分类号：

R71 [妇产科学];

学科分类号：

100211 ;

摘要：

The aim of the present study is to evaluate the treatment potential of Alchemilla mollis (Buser) Rothm. and Alchemilla persica Rothm. in the experimentally induced endometriosis model in rats. Endometriosis was surgically induced in rats by autotransplanting endometrial tissue to abdominal wall. Thirty-six rats were randomly divided into six groups. The groups were orally treated with the methanol:water (80:20) extracts of aerial parts and roots of A. mollis and A. persica. Buserelin acetate (20 mg) was used as the reference drug. The phytochemical contents of the most active extracts were determined by high performance liquid chromatography. The cystic formation was determined to be significantly decreased with the aerial part extract of A. mollis. A reduction in the endometrioma was also determined for the aerial part extract of A. persica group. However, significant reduction on the levels of cytokine were recorded for the A. mollis aerial part extract group. Therefore, the phytochemical contents of the aerial part extracts of A. mollis. and A. persica were analyzed. The results of the present study revealed that the aerial part extracts of A. mollis and A. persica could be beneficial in the treatment of endometriosis.

引用

页码：619 / 628

页数：10

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