Bioactive Carbazole Alkaloids from Clausena wallichii Roots

被引：152

作者：

Maneerat, Wisanu ^{[1
]}

Ritthiwigrom, Thunwadee ^{[2
]}

Cheenpracha, Sarot ^{[3
]}

Promgool, Trinop ^{[1
]}

Yossathera, Kulsiri ^{[1
]}

Deachathai, Suwanna ^{[1
]}

Phakhodee, Wong ^{[1
]}

Laphookhieo, Surat ^{[1
]}

机构：

[1] Mae Fah Luang Univ, Sch Sci, Nat Prod Res Lab, Muang 57100, Chiang Rai, Thailand

[2] Chiang Mai Univ, Fac Sci, Dept Chem, Chiang Mai 50200, Thailand

[3] Univ Phayao, Sch Sci, Muang 56000, Phayao, Thailand

来源：

JOURNAL OF NATURAL PRODUCTS | 2012年 / 75卷 / 04期

关键词：

STRUCTURAL ELUCIDATION; CHEMICAL-CONSTITUENTS; EXCAVATA; ISOLATION;

D O I：

10.1021/np3000365

中图分类号：

Q94 [植物学];

学科分类号：

071001 ;

摘要：

Four new carbazole alkaloids, clausenawallines C-F (1-4), along with 18 known compounds (5-22) were isolated from the roots of Clausena wallichii. Compounds 3, 9, and 22 exhibited significant antibacterial activity against methicillin-resistant Staphylococcus aureus SK1 (MRSA SK1) and Staph. aureus TISTR 1466 with MIC values in the range 4-16 mu g/mL, whereas compound 4 showed the highest cytotoxicity against oral cavity cancer (KB) and small-cell lung cancer (NCI-H187) with IC50 values of 10.2 and 4.5 mu M, respectively.

引用

页码：741 / 746

页数：6

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