Improved Endothelialisation on Nanostructured Surfaces

被引：10

作者：

Aktas, Cenk ^{[1
]}

Haidar, Ayman ^{[2
]}

Miro, Marina Martinez ^{[1
]}

Doerrschuck, Eva ^{[2
]}

Lee, Juseok ^{[1
]}

Veith, Michael ^{[1
,3
]}

Abdul-Khaliq, Hashim ^{[2
]}

机构：

[1] INM Leibniz Inst New Mat, CVD Biosurfaces Grp, D-66123 Saarbrucken, Germany

[2] Univ Saarland, Clin Paediatr Cardiol, D-66421 Homburg, Germany

[3] Univ Saarland, Dept Inorgan Chem, D-66123 Saarbrucken, Germany

来源：

ADVANCES IN INNOVATIVE MATERIALS AND APPLICATIONS | 2011年 / 324卷

关键词：

Restenosis; CVD; Nanowires; Cell-Surface Interactions; CELL-ADHESION; STENTS;

D O I：

10.4028/www.scientific.net/AMR.324.105

中图分类号：

T [工业技术];

学科分类号：

08 ;

摘要：

Topography plays a major role on surface-cell interaction beside the surface chemistry. We investigated the effect of the nanotopography on vascular cell adhesion and proliferation in order to improve endothelialisation for restenosis treatment. In this context, Al2O3 nanowires (NWs) composed of a stable Al2O3 shell and an Al core were synthesized by chemical vapour deposition (CVD) of the molecular precursor ((BuOAlH2)-Bu-t)(2). After the detailed material characterization, human umbilical vein endothelial cells (HUVEC) and human umbilical vein smooth muscle cells (HUVSMC) were seeded and cultivated on these surfaces. Our preliminary results showed that there is a preference of HUVEC adhesion on NWs in comparison to that of HUVSMC. The control of the cell surface interaction by the topography may represent a key issue for the future stent material design.

引用

页码：105 / +

页数：3

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