Modulating Anticancer Potential by Modifying the Structural Properties of a Family of Zinc Metal-Organic Chains Based on 4-Nitro-1H-pyrazole

被引：39

作者：

Fernandez, Belen ^{[1
]}

Fernandez, Ignacio ^{[2
]}

Cepeda, Javier ^{[4
]}

Medina-O'Donnell, Marta ^{[3
]}

Rufino-Palornares, Eva E. ^{[3
]}

Raya-Baron, Alvaro ^{[2
]}

Gomez-Ruiz, Santiago ^{[5
]}

Perez-Jimenez, Arnalia ^{[3
]}

Lupianez, Jose Antonio ^{[3
]}

Reyes-Zurita, Fernando J. ^{[3
]}

Rodriguez-Dieguez, Antonio ^{[1
]}

机构：

[1] Univ Granada, Dept Inorgan Chem, C Severo Ochoa S-N, E-18071 Granada, Spain

[2] Univ Almeria, Dept Chem & Phys, Res Ctr Agr & Food Biotechnol BITAL, Ctra Sacramento S-N, Almeria 04120, Spain

[3] Univ Granada, Dept Biochem, Severo Ochoa S-N, E-18071 Granada, Spain

[4] Univ Basque Country, UPV EHU, Dept Appl Chem, San Sebastian 20018, Spain

[5] Rey Juan Carlos Univ, Dept Biol & Geol, Phys & Inorgan Chem, C Tulipan S-N, Madrid 28933, Spain

来源：

CRYSTAL GROWTH & DESIGN | 2018年 / 18卷 / 02期

关键词：

FRAMEWORKS; CANCER; CYTOTOXICITY; FLUORESCENCE; COMPLEXES; DELIVERY; PYRAZOLE; CELLS;

D O I：

10.1021/acs.cgd.7b01443

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

We have synthesized a novel family of metal organic chains based on 4-nitro-1H-pyrazole linker and zinc as metal center. We report the formation of these coordination polymers using hydrothermal routes with water as solvent. These materials display one-dimensional structures with major structural modifications from minimal synthetic variations. What is more interesting, we have carried out antitumor measurements, and we have related these properties with the structural networks. To the best of our knowledge, these materials constitute the first examples of polymeric structures for 4-NO2- pz ligands. NMR and MS spectrometry were used to verify the characterization of the metal complexes in solution to corroborate that these materials are present in the biological assays.

引用

页码：969 / 978

页数：10

共 47 条

[1]

ADAMS GE, 1976, LANCET, V1, P186

[2] CHEMICAL RADIOSENSITIZATION OF HYPOXIC CELLS [J].

ADAMS, GE .

BRITISH MEDICAL BULLETIN, 1973, 29 (01) :48-53

[3] HYPOXIA-MEDIATED NITRO-HETEROCYCLIC DRUGS IN THE RADIOTHERAPY AND CHEMOTHERAPY OF CANCER - AN OVERVIEW [J].

ADAMS, GE ;

STRATFORD, IJ .

BIOCHEMICAL PHARMACOLOGY, 1986, 35 (01) :71-76

[4] SIR97:: a new tool for crystal structure determination and refinement [J].

Altomare, A ;

Burla, MC ;

Camalli, M ;

Cascarano, GL ;

Giacovazzo, C ;

Guagliardi, A ;

Moliterni, AGG ;

Polidori, G ;

Spagna, R .

JOURNAL OF APPLIED CRYSTALLOGRAPHY, 1999, 32 :115-119

[5]

[Anonymous], 1996, SADABS

[6] Synthesis and Characterization of Two Lanthanide (Gd3+ and Dy3+)-Based Three-Dimensional Metal Organic Frameworks with Squashed Metallomacrocycle Type Building Blocks and Their Magnetic, Sorption, and Fluorescence Properties Study [J].

Biswas, Soumava ;

Jena, Himanshu Sekhar ;

Goswami, Soumyabrata ;

Sanda, Suresh ;

Konar, Sanjit .

CRYSTAL GROWTH & DESIGN, 2014, 14 (03) :1287-1295

[7]

Bruker, 2004, APEX2

[8] Rare earth anthracenedicarboxylate metal-organic frameworks: slow relaxation of magnetization of Nd3+, Gd3+, Dy3+, Er3+ and Yb3+ based materials [J].

Calahorro, Antonio J. ;

Oyarzabal, Itziar ;

Fernandez, Belen ;

Seco, Jose M. ;

Tian, Tian ;

Fairen-Jimenez, David ;

Colacio, Enrique ;

Rodriguez-Dieguez, Antonio .

DALTON TRANSACTIONS, 2016, 45 (02) :591-598

[9] Luminescence and magnetic properties of three metal-organic frameworks based on the 5-(1H-tetrazol-5-yl)isophthalic acid ligand [J].

Calahorro, Antonio J. ;

Salinas-Castillo, Alfonso ;

Manuel Seco, Jose ;

Zuniga, Javier ;

Colacio, Enrique ;

Rodriguez-Dieguez, Antonio .

CRYSTENGCOMM, 2013, 15 (38) :7636-7639

[10] Tuning the luminescence performance of metal-organic frameworks based on d10 metal ions: from an inherent versatile behaviour to their response to external stimuli [J].

Cepeda, Javier ;

Rodriguez-Dieguez, Antonio .

CRYSTENGCOMM, 2016, 18 (44) :8556-8573

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