Transcriptional and epigenetic regulation in human islets

被引：10
作者：
Bramswig, Nuria C. [1 ,2 ]
Kaestner, Klaus H. [1 ,2 ]
机构：
[1] Univ Penn, Perelman Sch Med, Dept Genet, Translat Res Ctr 12 126, Philadelphia, PA 19104 USA
[2] Univ Penn, Perelman Sch Med, Inst Diabet Obes & Metab, Philadelphia, PA 19104 USA
来源：
DIABETOLOGIA | 2014年 / 57卷 / 03期
关键词：
Endocrine pancreas; Epigenetics; Epigenomics; Reprogramming; Review; Transcription; PANCREATIC-ISLETS; LIFE-STYLE; PROVIDES INSIGHTS; DNA METHYLATION; ALPHA-CELLS; EXPRESSION; ARCHITECTURE; SEQ;
D O I：
10.1007/s00125-013-3150-3
中图分类号：
R5 [内科学];
学科分类号：
1002 ; 100201 ;
摘要：
Gene regulation in human pancreatic endocrine cells is a complex process, governed by genetic and environmental factors and crosstalk between the various endocrine cell types, and between endocrine cells and the metabolic state. Recent advances in gene expression profiling, genome-wide analysis of epigenetic marks, and cell fractionation of human islets into their constitutive cell types have greatly increased our understanding of the complex processes that govern endocrine cell function in health and disease. Further progress in this area holds great promise for delivering new targets for the development of novel diabetes therapies.
引用
收藏
页码：451 / 454
页数：4
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