Efficacy and toxicity of plasmonic photothermal therapy (PPTT) using gold nanorods (GNRs) against mammary tumors in dogs and cats

被引：31
作者：
Abdoon, Ahmed S. [1 ]
Al-Ashkar, Emad A. [2 ]
Kandil, Omaima M. [1 ]
Shaban, Ahmed M. [3 ]
Khaled, Hussein M. [4 ]
El Sayed, Mostafa A. [5 ]
El Shaer, Marwa M. [6 ]
Shaalan, Asharaf H. [7 ]
Eisa, Wael H. [2 ]
Eldin, Amina A. Gamal [6 ]
Hussein, Hany A. [1 ]
El Ashkar, Mohammad R. [8 ]
Ali, Moustafa R. [5 ]
Shabaka, Ali A. [2 ]
机构：
[1] Natl Res Ctr, Dept Anim Reprod, Vet Res Div, Cairo 12622, Egypt
[2] NRC, Dept Spect, Cairo, Egypt
[3] NRC, Environm Res Div, Cairo, Egypt
[4] Cairo Univ, Natl Canc Inst, Giza, Giza Governorat, Egypt
[5] Georgia Inst Technol, Dept Chem & Biochem, Laser Dynam Lab, Atlanta, GA 30332 USA
[6] NRC, Div Med Res, Dept Pathol, Cairo, Egypt
[7] NRC, Div Med Res, Dept Biol Anthropol, Cairo, Egypt
[8] Pet Lovers Vet Clin, Cairo, Egypt
来源：
NANOMEDICINE-NANOTECHNOLOGY BIOLOGY AND MEDICINE | 2016年 / 12卷 / 08期
关键词：
Dogs and cats; Mammary tumors; Gold nanorods; Near infra-red light; Cytotoxicity; Toxicity; IN-VIVO; NANOPARTICLES; EXPOSURE; SIZE; MECHANISM; LIVER;
D O I：
10.1016/j.nano.2016.07.005
中图分类号：
TB3 [工程材料学];
学科分类号：
0805 ; 080502 ;
摘要：
Plasmonic photothermal therapy (PPTT) was introduced as a promising treatment of cancer. This work was conducted to evaluate the cytotoxic effect of intratumoral (IT) injection of 75 mu g gold nanorods (GNRs)/kg of body weight followed by direct exposure to 2 w/cm(2) near infra-red laser light for 10 min on ablation of mammary tumor in 10 dogs and 6 cats. Complete blood count (CBC), liver and kidney function were checked before the start of treatment and one month after injection of GNRs. Results showed that 62.5% (10/16), 25% (4/16) and 12.5% (2/16) of treated animals showed complete remission, partial remission and no response, respectively. Tumor was relapsed in 4 cases of initially responding animals (25%). Overall survival rate was extended to 315.5 +/- 20.5 days. GNRs have no toxic effect on blood profile, liver or kidney functions. In conclusion, GNRs can be safely used for treatment of mammary tumors in dogs and cats. (C) 2016 Elsevier Inc. All rights reserved.
引用
收藏
页码：2291 / 2297
页数：7
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