DNMT3A and TET2 Mutations: Linking Genetics and Epigenetics in Pulmonary Arterial Hypertension

被引:0
作者
Potus, F. [1 ]
Cook, E. K. [1 ]
Hsieh, A. [2 ]
Pauciulo, M. [3 ]
Welch, C. [2 ]
Zhu, N. [2 ]
Tian, L. [1 ]
Lima, P. [1 ]
D'Arsigny, C. [1 ]
Shen, Y. [2 ]
Hassoun, P. M. [4 ]
Nichols, W. C. [5 ]
Chung, W. K. [6 ]
Rauh, M. J. [7 ]
Archer, S. L. [1 ]
机构
[1] Queens Univ, Med, Kingston, ON, Canada
[2] Columbia Univ, New York, NY USA
[3] Cincinnati Childrens Hosp Med Ctr, Cincinnati, OH 45229 USA
[4] Johns Hopkins Univ, Sch Med, Div Pulm & Crit Care, Baltimore, MD USA
[5] Cincinnati Childrens Hosp Med Ctr, Div Human Genet, Cincinnati, OH 45229 USA
[6] Columbia Univ, Med, New York, NY USA
[7] Queens Univ, Kingston, ON, Canada
关键词
D O I
暂无
中图分类号
R4 [临床医学];
学科分类号
1002 ; 100602 ;
摘要
A2397
引用
收藏
页数:2
相关论文
共 50 条
  • [31] Correlation of DNA methylation of DNMT3A and TET2 with oral squamous cell carcinoma
    Li, Xueming
    Li, Zaikun
    Gao, Qingxi
    Peng, Yanan
    Yu, Yang
    Hu, Tenglong
    Wang, Wei
    DISCOVER ONCOLOGY, 2024, 15 (01)
  • [32] TET2 and DNMT3A mutations and exceptional response to 4′-thio-2′-deoxycytidine in human solid tumor models
    Sherry X. Yang
    Melinda Hollingshead
    Larry Rubinstein
    Dat Nguyen
    Angelo B. A. Larenjeira
    Robert J. Kinders
    Michael Difilippantonio
    James H. Doroshow
    Journal of Hematology & Oncology, 14
  • [33] TET2 and DNMT3A Mutations Exert Divergent Effects on DNA Repair and Sensitivity of Leukemia Cells to PARP Inhibitors
    Maifrede, Silvia
    Le, Bac Viet
    Nieborowska-Skorska, Margaret
    Golovine, Konstantin
    Sullivan-Reed, Katherine
    Dunuwille, Wangisa M. B.
    Nacson, Joseph
    Hulse, Michael
    Keith, Kelsey
    Madzo, Jozef
    Caruso, Lisa Beatrice
    Gazze, Zachary
    Lian, Zhaorui
    Padella, Antonella
    Chitrala, Kumaraswamy N.
    Bartholdy, Boris A.
    Matlawska-Wasowska, Ksenia
    Di Marcantonio, Daniela
    Simonetti, Giorgia
    Greiner, Georg
    Sykes, Stephen M.
    Valent, Peter
    Paietta, Elisabeth M.
    Tallman, Martin S.
    Fernandez, Hugo F.
    Litzow, Mark R.
    Minden, Mark D.
    Huang, Jian
    Martinelli, Giovanni
    Vassiliou, George S.
    Tempera, Italo
    Piwocka, Katarzyna
    Johnson, Neil
    Challen, Grant A.
    Skorski, Tomasz
    CANCER RESEARCH, 2021, 81 (19) : 5089 - 5101
  • [34] TET2 and DNMT3A mutations and exceptional response to 4′-thio-2′-deoxycytidine in human solid tumor models
    Yang, Sherry X.
    Hollingshead, Melinda
    Rubinstein, Larry
    Nguyen, Dat
    Larenjeira, Angelo B. A.
    Kinders, Robert J.
    Difilippantonio, Michael
    Doroshow, James H.
    JOURNAL OF HEMATOLOGY & ONCOLOGY, 2021, 14 (01)
  • [35] Clonal Hematopoiesis Associated With TET2 and DNMT3A Gene Driver Mutations Accelerates Aortic Valve Calcification in vitro and in vivo
    Abplanalp, Wesley T.
    Schuhmacher, Bianca
    Mas-Peiro, Silvia
    Zuriaga, Maria A.
    Matesanz, Nuria
    Fuster, Jose J.
    John, David
    Muhly-Reinholz, Marion
    Vasa-Nicotera, Mariuca
    Merten, Maximilian
    Hoffmann, Jedrzej
    Zeiher, Andreas M.
    Dimmeler, Stefanie
    CIRCULATION, 2022, 146
  • [36] OPPOSING EFFECTS OF DNMT3A AND TET2 CLONAL HEMATOPOIESIS ON ALZHEIMER'S DISEASE PATHOGENESIS
    Matatall, Katie
    Wathan, Trisha
    Florez, Marcus
    Fernandez-Sanchez, Josaura
    Le, Duy
    Maknojia, Arushana
    Rodriguez, Antony
    King, Katherine
    EXPERIMENTAL HEMATOLOGY, 2024, 137
  • [37] Sole DNMT3A/TET2/ASXL1 Mutations Define a Distinct Clinical Trajectory for Patients with Clonal Hematopoiesis
    Patel, Shyam Ajay
    Gerber, William K.
    Zheng, Rena
    Khanna, Shrinkhala
    Hutchinson, Lloyd
    Cerny, Jan
    Dasilva, Brandon
    Zhang, Tian Y.
    Khedr, Salwa
    Selove, William
    Woda, Bruce
    Abel, Gregory A.
    Miron, Patricia Minehart
    Higgins, Anne
    Gerber, Jonathan M.
    BLOOD, 2023, 142
  • [38] OPPOSING EFFECTS OF DNMT3A AND TET2 CLONAL HEMATOPOIESIS ON ALZHEIMER'S DISEASE PATHOGENESIS
    Matatall, Katie
    Wathan, Trisha
    Florez, Marcus
    Fernandez-Sanchez, Josaura
    Le, Duy
    Maknojia, Arushana
    Rodriguez, Antony
    King, Katherine
    EXPERIMENTAL HEMATOLOGY, 2024, 137
  • [39] Combined heterozygosity of FLT3ITD, TET2, and DNMT3A results in aggressive leukemia
    Ramdas, Baskar
    Reddy, Palam Lakshmi
    Mali, Raghuveer Singh
    Pasupuleti, Santhosh Kumar
    Zhang, Ji
    Kelley, Mark R.
    Paczesny, Sophie
    Zhang, Chi
    Kapur, Reuben
    JCI INSIGHT, 2022, 7 (17)
  • [40] Thrombotic Risk Detection in Patients with Polycythemia Vera: The Predictive Role of DNMT3A/TET2/ASXL1 Mutations
    Segura-Diaz, Adrian
    Stuckey, Ruth
    Florido, Yanira
    Maria Gonzalez-Martin, Jesus
    Francisco Lopez-Rodriguez, Juan
    Sanchez-Sosa, Santiago
    Gonzalez-Perez, Elena
    Saez Perdomo, Maria Nieves
    del Mar Perera, Maria
    de la Iglesia, Silvia
    Molero-Labarta, Teresa
    Teresa Gomez-Casares, Maria
    Bilbao-Sieyro, Cristina
    CANCERS, 2020, 12 (04)